Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036169904> ?p ?o ?g. }
- W3036169904 endingPage "949" @default.
- W3036169904 startingPage "938" @default.
- W3036169904 abstract "The central nervous system (CNS) is classically viewed as immune-privileged; however, recent advances highlight interactions between the peripheral immune system and CNS in controlling infections and tissue homeostasis. Tissue-resident memory (TRM) CD8+ T cells in the CNS are generated after brain infections, but it is unknown whether CNS infection is required to generate brain TRM cells. We show that peripheral infections generate antigen-specific CD8+ memory T cells in the brain that adopt a unique TRM signature. Upon depletion of circulating and perivascular memory T cells, this brain signature was enriched and the surveilling properties of brain TRM cells was revealed by intravital imaging. Notably, peripherally induced brain TRM cells showed evidence of rapid activation and enhanced cytokine production and mediated protection after brain infections. These data reveal that peripheral immunizations can generate brain TRM cells and will guide potential use of T cells as therapeutic strategies against CNS infections and neurological diseases. Harty and colleagues show that peripheral infections can establish and maintain functional antigen-specific tissue-resident memory CD8+ T cells in the central nervous system." @default.
- W3036169904 created "2020-06-25" @default.
- W3036169904 creator A5008319091 @default.
- W3036169904 creator A5044206698 @default.
- W3036169904 creator A5056006599 @default.
- W3036169904 creator A5056601544 @default.
- W3036169904 creator A5061261855 @default.
- W3036169904 creator A5064482493 @default.
- W3036169904 creator A5090796277 @default.
- W3036169904 date "2020-06-22" @default.
- W3036169904 modified "2023-10-17" @default.
- W3036169904 title "Peripherally induced brain tissue–resident memory CD8+ T cells mediate protection against CNS infection" @default.
- W3036169904 cites W1588685142 @default.
- W3036169904 cites W1795093163 @default.
- W3036169904 cites W1918237073 @default.
- W3036169904 cites W1972712314 @default.
- W3036169904 cites W1986432489 @default.
- W3036169904 cites W2012364722 @default.
- W3036169904 cites W2021115043 @default.
- W3036169904 cites W2024626836 @default.
- W3036169904 cites W2025745949 @default.
- W3036169904 cites W2052275203 @default.
- W3036169904 cites W2060530677 @default.
- W3036169904 cites W2069749184 @default.
- W3036169904 cites W2087355181 @default.
- W3036169904 cites W2100609582 @default.
- W3036169904 cites W2107838849 @default.
- W3036169904 cites W2113628320 @default.
- W3036169904 cites W2116070441 @default.
- W3036169904 cites W2127716652 @default.
- W3036169904 cites W2128629993 @default.
- W3036169904 cites W2137327945 @default.
- W3036169904 cites W2163001100 @default.
- W3036169904 cites W2266090185 @default.
- W3036169904 cites W2273021913 @default.
- W3036169904 cites W2293892300 @default.
- W3036169904 cites W2336322268 @default.
- W3036169904 cites W2467438710 @default.
- W3036169904 cites W2515274402 @default.
- W3036169904 cites W2557821298 @default.
- W3036169904 cites W2559909402 @default.
- W3036169904 cites W2560258181 @default.
- W3036169904 cites W2569985415 @default.
- W3036169904 cites W2585996473 @default.
- W3036169904 cites W2588304745 @default.
- W3036169904 cites W2595908170 @default.
- W3036169904 cites W2599795883 @default.
- W3036169904 cites W2605592326 @default.
- W3036169904 cites W2607079475 @default.
- W3036169904 cites W2626725198 @default.
- W3036169904 cites W2774264760 @default.
- W3036169904 cites W2778016195 @default.
- W3036169904 cites W2782270041 @default.
- W3036169904 cites W2791192045 @default.
- W3036169904 cites W2795270277 @default.
- W3036169904 cites W2795704872 @default.
- W3036169904 cites W2799971017 @default.
- W3036169904 cites W2803092602 @default.
- W3036169904 cites W2885490686 @default.
- W3036169904 cites W2890386758 @default.
- W3036169904 cites W2899073628 @default.
- W3036169904 cites W2899192123 @default.
- W3036169904 cites W2900562404 @default.
- W3036169904 cites W2903124759 @default.
- W3036169904 cites W2914668666 @default.
- W3036169904 cites W2954434934 @default.
- W3036169904 cites W3000319248 @default.
- W3036169904 doi "https://doi.org/10.1038/s41590-020-0711-8" @default.
- W3036169904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7381383" @default.
- W3036169904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32572242" @default.
- W3036169904 hasPublicationYear "2020" @default.
- W3036169904 type Work @default.
- W3036169904 sameAs 3036169904 @default.
- W3036169904 citedByCount "68" @default.
- W3036169904 countsByYear W30361699042020 @default.
- W3036169904 countsByYear W30361699042021 @default.
- W3036169904 countsByYear W30361699042022 @default.
- W3036169904 countsByYear W30361699042023 @default.
- W3036169904 crossrefType "journal-article" @default.
- W3036169904 hasAuthorship W3036169904A5008319091 @default.
- W3036169904 hasAuthorship W3036169904A5044206698 @default.
- W3036169904 hasAuthorship W3036169904A5056006599 @default.
- W3036169904 hasAuthorship W3036169904A5056601544 @default.
- W3036169904 hasAuthorship W3036169904A5061261855 @default.
- W3036169904 hasAuthorship W3036169904A5064482493 @default.
- W3036169904 hasAuthorship W3036169904A5090796277 @default.
- W3036169904 hasBestOaLocation W30361699042 @default.
- W3036169904 hasConcept C147483822 @default.
- W3036169904 hasConcept C154317977 @default.
- W3036169904 hasConcept C167672396 @default.
- W3036169904 hasConcept C169760540 @default.
- W3036169904 hasConcept C202751555 @default.
- W3036169904 hasConcept C203014093 @default.
- W3036169904 hasConcept C529278444 @default.
- W3036169904 hasConcept C55493867 @default.
- W3036169904 hasConcept C86803240 @default.
- W3036169904 hasConcept C8891405 @default.
- W3036169904 hasConceptScore W3036169904C147483822 @default.