FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036173165> ?p ?o ?g. }

• W3036173165 endingPage "237" @default.
• W3036173165 startingPage "231" @default.
• W3036173165 abstract "Estrogen receptor beta (ERβ), encoded by the Esr2 gene, is one of two nuclear receptors that mediate the functions of the steroid hormone estradiol. The binding of estradiol to the receptor results in enhanced transcription of many genes that have estrogen response elements in promoter or enhancer regions. Several genetically modified mouse lines with mutations or deletions of exons in the Esr2 gene have been developed and results from analysis of these are not completely consistent, especially regarding ERβ′s role in fertility. To address these controversies, we have used the CRISPR/Cas9 genome editing system to make a deletion of the entire Esr2 gene in the mouse genome and determined the effect of this mutation on fertility. We show that female Esr2 deleted mice, Esr2ΔE1−10, are subfertile at young age, with fewer litters and smaller litter size, and that they become infertile/have severely reduced fertility at around six months of age, while the male Esr2ΔE1−10 mice are fertile. Ovaries from Esr2ΔE1−10 mice are smaller than those from wild-type littermates and the morphology of the ovary displays very few corpora lutea, indicating a defect in ovulation. We also show that the estradiol levels are reduced at diestrus, the phase in the estrous cycle when levels are expected to start to increase before ovulation. Our results verify that ERβ has an important function in female reproduction, likely as a regulator of serum estradiol levels, and that its loss does not affect male reproductive function." @default.
• W3036173165 created "2020-06-25" @default.
• W3036173165 creator A5009667881 @default.
• W3036173165 creator A5017990600 @default.
• W3036173165 creator A5033325644 @default.
• W3036173165 creator A5036193907 @default.
• W3036173165 creator A5039779401 @default.
• W3036173165 creator A5057390896 @default.
• W3036173165 creator A5064220321 @default.
• W3036173165 creator A5091032474 @default.
• W3036173165 date "2020-08-01" @default.
• W3036173165 modified "2023-09-30" @default.
• W3036173165 title "Generation of an all-exon Esr2 deleted mouse line: Effects on fertility" @default.
• W3036173165 cites W1977709885 @default.
• W3036173165 cites W1981306061 @default.
• W3036173165 cites W1993005991 @default.
• W3036173165 cites W2006115622 @default.
• W3036173165 cites W2006727096 @default.
• W3036173165 cites W2006770469 @default.
• W3036173165 cites W2012425172 @default.
• W3036173165 cites W2013865699 @default.
• W3036173165 cites W2014455593 @default.
• W3036173165 cites W2023477238 @default.
• W3036173165 cites W2043659942 @default.
• W3036173165 cites W2059366188 @default.
• W3036173165 cites W2065785294 @default.
• W3036173165 cites W2073353512 @default.
• W3036173165 cites W2080599802 @default.
• W3036173165 cites W2083843527 @default.
• W3036173165 cites W2099569610 @default.
• W3036173165 cites W2101022457 @default.
• W3036173165 cites W2120653485 @default.
• W3036173165 cites W2121454015 @default.
• W3036173165 cites W2133282757 @default.
• W3036173165 cites W2141269411 @default.
• W3036173165 cites W2171466896 @default.
• W3036173165 cites W2615648215 @default.
• W3036173165 cites W2625984598 @default.
• W3036173165 cites W2883140774 @default.
• W3036173165 cites W2887591032 @default.
• W3036173165 cites W2894831682 @default.
• W3036173165 cites W2996124444 @default.
• W3036173165 cites W4249175134 @default.
• W3036173165 doi "https://doi.org/10.1016/j.bbrc.2020.06.063" @default.
• W3036173165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32703416" @default.
• W3036173165 hasPublicationYear "2020" @default.
• W3036173165 type Work @default.
• W3036173165 sameAs 3036173165 @default.
• W3036173165 citedByCount "12" @default.
• W3036173165 countsByYear W30361731652021 @default.
• W3036173165 countsByYear W30361731652022 @default.
• W3036173165 countsByYear W30361731652023 @default.
• W3036173165 crossrefType "journal-article" @default.
• W3036173165 hasAuthorship W3036173165A5009667881 @default.
• W3036173165 hasAuthorship W3036173165A5017990600 @default.
• W3036173165 hasAuthorship W3036173165A5033325644 @default.
• W3036173165 hasAuthorship W3036173165A5036193907 @default.
• W3036173165 hasAuthorship W3036173165A5039779401 @default.
• W3036173165 hasAuthorship W3036173165A5057390896 @default.
• W3036173165 hasAuthorship W3036173165A5064220321 @default.
• W3036173165 hasAuthorship W3036173165A5091032474 @default.
• W3036173165 hasBestOaLocation W30361731651 @default.
• W3036173165 hasConcept C104317684 @default.
• W3036173165 hasConcept C121608353 @default.
• W3036173165 hasConcept C126322002 @default.
• W3036173165 hasConcept C134018914 @default.
• W3036173165 hasConcept C172313692 @default.
• W3036173165 hasConcept C1998276 @default.
• W3036173165 hasConcept C2777164284 @default.
• W3036173165 hasConcept C2777702977 @default.
• W3036173165 hasConcept C2778324911 @default.
• W3036173165 hasConcept C36823959 @default.
• W3036173165 hasConcept C530470458 @default.
• W3036173165 hasConcept C54355233 @default.
• W3036173165 hasConcept C71315377 @default.
• W3036173165 hasConcept C71924100 @default.
• W3036173165 hasConcept C84606932 @default.
• W3036173165 hasConcept C86803240 @default.
• W3036173165 hasConceptScore W3036173165C104317684 @default.
• W3036173165 hasConceptScore W3036173165C121608353 @default.
• W3036173165 hasConceptScore W3036173165C126322002 @default.
• W3036173165 hasConceptScore W3036173165C134018914 @default.
• W3036173165 hasConceptScore W3036173165C172313692 @default.
• W3036173165 hasConceptScore W3036173165C1998276 @default.
• W3036173165 hasConceptScore W3036173165C2777164284 @default.
• W3036173165 hasConceptScore W3036173165C2777702977 @default.
• W3036173165 hasConceptScore W3036173165C2778324911 @default.
• W3036173165 hasConceptScore W3036173165C36823959 @default.
• W3036173165 hasConceptScore W3036173165C530470458 @default.
• W3036173165 hasConceptScore W3036173165C54355233 @default.
• W3036173165 hasConceptScore W3036173165C71315377 @default.
• W3036173165 hasConceptScore W3036173165C71924100 @default.
• W3036173165 hasConceptScore W3036173165C84606932 @default.
• W3036173165 hasConceptScore W3036173165C86803240 @default.
• W3036173165 hasFunder F4320322581 @default.
• W3036173165 hasFunder F4320336663 @default.
• W3036173165 hasIssue "2" @default.
• W3036173165 hasLocation W30361731651 @default.

• next