Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036183998> ?p ?o ?g. }
- W3036183998 abstract "Abstract Treatment personalisation remains an unmet need in oropharynx cancer (OPC). We aimed to determine whether gene expression signatures improved upon clinico-pathological predictors of outcome in OPC. The clinico-pathological predictors, AJCC version 7 (AJCC 7), AJCC 8, and a clinical algorithm, were assessed in 4 public series of OPC (n = 235). Literature review identified 16 mRNA gene expression signatures of radiosensitivity, HPV status, tumour hypoxia, and microsatellite instability. We quality tested signatures using a novel sigQC methodology, and added signatures to clinico-pathological variables as predictors of survival, in univariate and multivariate analyses. AJCC 7 Stage was not predictive of recurrence-free survival (RFS) or overall survival (OS). AJCC 8 significantly predicted RFS and OS. Gene signature quality was highly variable. Among HPV-positive cases, signatures for radiosensitivity, hypoxia, and microsatellite instability revealed significant underlying inter-tumour biological heterogeneity, but did not show prognostic significance when adjusted for clinical covariates. Surprisingly, among HPV-negative cases, a gene signature for HPV status was predictive of survival, even after adjustment for clinical covariates. Across the whole series, several gene signatures representing HPV and microsatellite instability remained significant in multivariate analysis. However, quality control and independent validation remain to be performed to add prognostic information above recently improved clinico-pathological variables." @default.
- W3036183998 created "2020-06-25" @default.
- W3036183998 creator A5005373482 @default.
- W3036183998 creator A5013313611 @default.
- W3036183998 creator A5039691995 @default.
- W3036183998 creator A5044648533 @default.
- W3036183998 creator A5054444820 @default.
- W3036183998 creator A5074810786 @default.
- W3036183998 creator A5075865182 @default.
- W3036183998 creator A5079633934 @default.
- W3036183998 creator A5086192492 @default.
- W3036183998 date "2020-06-23" @default.
- W3036183998 modified "2023-09-24" @default.
- W3036183998 title "Role of gene signatures combined with pathology in classification of oropharynx head and neck cancer" @default.
- W3036183998 cites W1240469554 @default.
- W3036183998 cites W1496107432 @default.
- W3036183998 cites W1533674874 @default.
- W3036183998 cites W1967202761 @default.
- W3036183998 cites W1974875034 @default.
- W3036183998 cites W1976116300 @default.
- W3036183998 cites W1985213644 @default.
- W3036183998 cites W1985585626 @default.
- W3036183998 cites W1986241711 @default.
- W3036183998 cites W1998096683 @default.
- W3036183998 cites W1999574084 @default.
- W3036183998 cites W2010494005 @default.
- W3036183998 cites W2024592737 @default.
- W3036183998 cites W2032780125 @default.
- W3036183998 cites W2069628816 @default.
- W3036183998 cites W2076419931 @default.
- W3036183998 cites W2081123985 @default.
- W3036183998 cites W2084116712 @default.
- W3036183998 cites W2093292614 @default.
- W3036183998 cites W2094202982 @default.
- W3036183998 cites W2110453313 @default.
- W3036183998 cites W2110480159 @default.
- W3036183998 cites W2110664940 @default.
- W3036183998 cites W2114119309 @default.
- W3036183998 cites W2121937591 @default.
- W3036183998 cites W2123526038 @default.
- W3036183998 cites W2129247180 @default.
- W3036183998 cites W2132239791 @default.
- W3036183998 cites W2145300644 @default.
- W3036183998 cites W2148028028 @default.
- W3036183998 cites W2152842543 @default.
- W3036183998 cites W2282180989 @default.
- W3036183998 cites W2340636398 @default.
- W3036183998 cites W2405994214 @default.
- W3036183998 cites W2566074209 @default.
- W3036183998 cites W2579941249 @default.
- W3036183998 cites W2607491790 @default.
- W3036183998 cites W2729030720 @default.
- W3036183998 cites W2778365321 @default.
- W3036183998 cites W2910156730 @default.
- W3036183998 cites W2937871094 @default.
- W3036183998 cites W2955639284 @default.
- W3036183998 cites W4230713242 @default.
- W3036183998 cites W4249522930 @default.
- W3036183998 doi "https://doi.org/10.1038/s41598-020-66983-x" @default.
- W3036183998 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7311543" @default.
- W3036183998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32576885" @default.
- W3036183998 hasPublicationYear "2020" @default.
- W3036183998 type Work @default.
- W3036183998 sameAs 3036183998 @default.
- W3036183998 citedByCount "9" @default.
- W3036183998 countsByYear W30361839982021 @default.
- W3036183998 countsByYear W30361839982022 @default.
- W3036183998 countsByYear W30361839982023 @default.
- W3036183998 crossrefType "journal-article" @default.
- W3036183998 hasAuthorship W3036183998A5005373482 @default.
- W3036183998 hasAuthorship W3036183998A5013313611 @default.
- W3036183998 hasAuthorship W3036183998A5039691995 @default.
- W3036183998 hasAuthorship W3036183998A5044648533 @default.
- W3036183998 hasAuthorship W3036183998A5054444820 @default.
- W3036183998 hasAuthorship W3036183998A5074810786 @default.
- W3036183998 hasAuthorship W3036183998A5075865182 @default.
- W3036183998 hasAuthorship W3036183998A5079633934 @default.
- W3036183998 hasAuthorship W3036183998A5086192492 @default.
- W3036183998 hasBestOaLocation W30361839981 @default.
- W3036183998 hasConcept C104317684 @default.
- W3036183998 hasConcept C10515644 @default.
- W3036183998 hasConcept C105795698 @default.
- W3036183998 hasConcept C121608353 @default.
- W3036183998 hasConcept C126322002 @default.
- W3036183998 hasConcept C142724271 @default.
- W3036183998 hasConcept C143998085 @default.
- W3036183998 hasConcept C150194340 @default.
- W3036183998 hasConcept C161584116 @default.
- W3036183998 hasConcept C180754005 @default.
- W3036183998 hasConcept C199163554 @default.
- W3036183998 hasConcept C207886595 @default.
- W3036183998 hasConcept C2776530083 @default.
- W3036183998 hasConcept C2779660593 @default.
- W3036183998 hasConcept C2779733811 @default.
- W3036183998 hasConcept C2779767149 @default.
- W3036183998 hasConcept C2993415550 @default.
- W3036183998 hasConcept C33923547 @default.
- W3036183998 hasConcept C38180746 @default.
- W3036183998 hasConcept C54355233 @default.
- W3036183998 hasConcept C61320498 @default.