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- W3036185872 endingPage "1664" @default.
- W3036185872 startingPage "1664" @default.
- W3036185872 abstract "Histones are the main structural proteins of eukaryotic chromatin. Histone acetylation/ deacetylation are the epigenetic mechanisms of the regulation of gene expression and are catalyzed by histone acetyltransferases (HAT) and histone deacetylases (HDAC). These epigenetic alterations of DNA structure influence the action of transcription factors which can induce or repress gene transcription. The HATs catalyze acetylation and the events related to gene transcription and are also responsible for transporting newly synthesized histones from the cytoplasm to the nucleus. The activity of HDACs is mainly involved in silencing gene expression and according to their specialized functions are divided into classes I, II, III and IV. The disturbance of the expression and mutations of HDAC genes causes the aberrant transcription of key genes regulating important cancer pathways such as cell proliferation, cell-cycle regulation and apoptosis. In view of their role in cancer pathways, HDACs are considered promising therapeutic targets and the development of HDAC inhibitors is a hot topic in the search for new anticancer drugs. The present review will focus on HDACs I, II and IV, the best known inhibitors and potential alternative inhibitors derived from natural and synthetic products which can be used to influence HDAC activity and the development of new cancer therapies." @default.
- W3036185872 created "2020-06-25" @default.
- W3036185872 creator A5007604587 @default.
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- W3036185872 creator A5036847174 @default.
- W3036185872 creator A5060590238 @default.
- W3036185872 creator A5062486430 @default.
- W3036185872 date "2020-06-23" @default.
- W3036185872 modified "2023-10-10" @default.
- W3036185872 title "Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy" @default.
- W3036185872 cites W1007961504 @default.
- W3036185872 cites W1490746234 @default.
- W3036185872 cites W1493846190 @default.
- W3036185872 cites W1504303645 @default.
- W3036185872 cites W1511815964 @default.
- W3036185872 cites W1516453481 @default.
- W3036185872 cites W1525573602 @default.
- W3036185872 cites W1547154484 @default.
- W3036185872 cites W1556859072 @default.
- W3036185872 cites W1562829163 @default.
- W3036185872 cites W1597656413 @default.
- W3036185872 cites W1604068141 @default.
- W3036185872 cites W1631785784 @default.
- W3036185872 cites W17355599 @default.
- W3036185872 cites W1774590633 @default.
- W3036185872 cites W1784857457 @default.
- W3036185872 cites W1792088282 @default.
- W3036185872 cites W18353697 @default.
- W3036185872 cites W1910848366 @default.
- W3036185872 cites W1923015860 @default.
- W3036185872 cites W1937607074 @default.
- W3036185872 cites W1964233786 @default.
- W3036185872 cites W1964473274 @default.
- W3036185872 cites W1964757070 @default.
- W3036185872 cites W1965812853 @default.
- W3036185872 cites W1966135423 @default.
- W3036185872 cites W1966163762 @default.
- W3036185872 cites W1966472337 @default.
- W3036185872 cites W1967018540 @default.
- W3036185872 cites W1968076212 @default.
- W3036185872 cites W1969044026 @default.
- W3036185872 cites W1970658265 @default.
- W3036185872 cites W1970990212 @default.
- W3036185872 cites W1973262157 @default.
- W3036185872 cites W1974112332 @default.
- W3036185872 cites W1974901513 @default.
- W3036185872 cites W1976470813 @default.
- W3036185872 cites W1977599117 @default.
- W3036185872 cites W1978016743 @default.
- W3036185872 cites W1978893041 @default.
- W3036185872 cites W1980131884 @default.
- W3036185872 cites W1980854517 @default.
- W3036185872 cites W1981209922 @default.
- W3036185872 cites W1985425266 @default.
- W3036185872 cites W1986179131 @default.
- W3036185872 cites W1987366741 @default.
- W3036185872 cites W1988995986 @default.
- W3036185872 cites W1989561482 @default.
- W3036185872 cites W1990353372 @default.
- W3036185872 cites W1991654592 @default.
- W3036185872 cites W1991718508 @default.
- W3036185872 cites W1992392607 @default.
- W3036185872 cites W1992519564 @default.
- W3036185872 cites W1993362950 @default.
- W3036185872 cites W1993711510 @default.
- W3036185872 cites W1996036500 @default.
- W3036185872 cites W1996103159 @default.
- W3036185872 cites W1996141260 @default.
- W3036185872 cites W1996507777 @default.
- W3036185872 cites W1997149430 @default.
- W3036185872 cites W1997166178 @default.
- W3036185872 cites W1997889012 @default.
- W3036185872 cites W1998158490 @default.
- W3036185872 cites W2005414132 @default.
- W3036185872 cites W2005993314 @default.
- W3036185872 cites W2007139310 @default.
- W3036185872 cites W2008156174 @default.
- W3036185872 cites W2009860272 @default.
- W3036185872 cites W2010833137 @default.
- W3036185872 cites W2011055851 @default.
- W3036185872 cites W2011263116 @default.
- W3036185872 cites W2012593128 @default.
- W3036185872 cites W2013571070 @default.
- W3036185872 cites W2014290632 @default.
- W3036185872 cites W2014817033 @default.
- W3036185872 cites W2018272903 @default.
- W3036185872 cites W2019474060 @default.
- W3036185872 cites W2020769038 @default.
- W3036185872 cites W2023401613 @default.
- W3036185872 cites W2026099958 @default.
- W3036185872 cites W2026387044 @default.
- W3036185872 cites W2026694991 @default.
- W3036185872 cites W2027171343 @default.
- W3036185872 cites W2027619236 @default.
- W3036185872 cites W2028178274 @default.
- W3036185872 cites W2029148944 @default.
- W3036185872 cites W2030309325 @default.
- W3036185872 cites W2031050288 @default.