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- W3036213835 abstract "Developmental malformations of the cardiovascular system are relatively common and well known. Less well known is the fact that this system may play an important role in the genesis of non-cardiovascular defects. Specifically, pilot studies indicated that caudal malformations in lead treated chick embryos are directly caused by a preceding cardiovascular abnormality; the presence of a large, blood filled caudal hematoma. These hematomas develop 16 to 24 hours after 20 μl of a lead nitrate solution (10 mM) is administered subgerminally on the second day of incubation. Small breaks and ultrastructural changes within the caudal embryonic dorsal aorta were observed as early as 4 hours after treatment. As these hematomas expand, they compress the surrounding soft embryonic tissues, destroying both the spatial relationships between tissues and the integrity of the tissues themselves. Pyknosis follows rapidly, and ultimately the dead or dying tissues and the hematoma itself are resorbed leading to a condition known as rumplessness (caudal dysplasia in humans). Within a short time of the formation of the initial hematoma, a tissue deficit is the only sign that a cardiovascular anomaly has occured." @default.
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- W3036213835 date "1983-08-01" @default.
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- W3036213835 title "X-ray microanalysis of embryonic tissue exposed to lead" @default.
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- W3036213835 doi "https://doi.org/10.1017/s0424820100076937" @default.
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