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- W3036216234 abstract "Hodgkin lymphoma (HL) is a unique type of hematopoietic cancer that has few tumor cells but a massive infiltration of immune cells. Findings on how the cancerous Hodgkin and Reed-Sternberg (HRS) cells survive and evade immune surveillance have facilitated the development of novel immunotherapies for HL. Trogocytosis is a fast process of intercellular transfer of membrane patches, which can significantly affect immune responses. In this review, we summarize the current knowledge of how trogocytosis contributes to the suppression of immune responses in HL. We focus on the ectopic expression of CD137 on HRS cells, the cause of its expression, and its implication on developing novel therapies for HL. Further, we review data demonstrating that similar mechanisms apply to CD30, PD-L1 and CTLA-4." @default.
- W3036216234 created "2020-06-25" @default.
- W3036216234 creator A5045088174 @default.
- W3036216234 creator A5075692347 @default.
- W3036216234 date "2020-01-01" @default.
- W3036216234 modified "2023-10-17" @default.
- W3036216234 title "The role of trogocytosis in immune surveillance of Hodgkin lymphoma" @default.
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- W3036216234 doi "https://doi.org/10.1080/2162402x.2020.1781334" @default.
- W3036216234 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7466850" @default.
- W3036216234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32934884" @default.
- W3036216234 hasPublicationYear "2020" @default.
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