Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036217148> ?p ?o ?g. }
- W3036217148 endingPage "136" @default.
- W3036217148 startingPage "127" @default.
- W3036217148 abstract "Abstract Purpose The aim of the present study was to understand the molecular and genetic alterations involved in follicular fluid oxidative process by investigating human mural granulosa cells and to find possible biomarkers for oocyte competency and ICSI outcome measures. Methods A total of 166 patients were included in the study. Total antioxidant and oxidant levels of follicular fluids were measured on the day of oocyte pick-up and oxidative status were calculated. Expression profiles of three potential target proteins in cases of oxidative stress (Hsp70, Tgf-β, Notch1), DNA status and chromatin integrity of mural granulosa cells were analyzed. Results TAS levels were positively correlated with the Hsp70 and Tgf-β expression patterns of mural granulosa cells. Mature oocyte rate and fertilization rates were affected negatively by the presence of oxidative stress and a significant positive correlation was found with the oxidative status and the fertilization rate, whereas no correlation with the remaining ICSI parameters in the overall group. Conclusions: Oxidative stress detected in follicular fluid adversely affects fertilization rates post-ICSI however no effect on the remaining parameters including embryo quality, pregnancy, and implantation rates. DNA damage, chromatin integrity were increased, whereas Hsp70 and Tgf-s were decreased in mural granulosa cells in cases of oxidative stress which may indirectly reflect the oocyte competency and may be used as biomarkers for ICSI outcome measures." @default.
- W3036217148 created "2020-06-25" @default.
- W3036217148 creator A5021596868 @default.
- W3036217148 creator A5021672104 @default.
- W3036217148 creator A5031075883 @default.
- W3036217148 creator A5032055042 @default.
- W3036217148 creator A5035634278 @default.
- W3036217148 date "2020-09-01" @default.
- W3036217148 modified "2023-10-03" @default.
- W3036217148 title "Effects of follicular fluid oxidative status on human mural granulosa cells, oocyte competency and ICSI parameters" @default.
- W3036217148 cites W1508699815 @default.
- W3036217148 cites W179707941 @default.
- W3036217148 cites W1966011370 @default.
- W3036217148 cites W1967090815 @default.
- W3036217148 cites W1968846402 @default.
- W3036217148 cites W1973973780 @default.
- W3036217148 cites W1975681729 @default.
- W3036217148 cites W1976464405 @default.
- W3036217148 cites W1976540956 @default.
- W3036217148 cites W1978592015 @default.
- W3036217148 cites W1981701710 @default.
- W3036217148 cites W1982818510 @default.
- W3036217148 cites W1983309364 @default.
- W3036217148 cites W1985031521 @default.
- W3036217148 cites W1988497057 @default.
- W3036217148 cites W1989410220 @default.
- W3036217148 cites W1994174822 @default.
- W3036217148 cites W1998688081 @default.
- W3036217148 cites W2002572737 @default.
- W3036217148 cites W2003106727 @default.
- W3036217148 cites W2010580307 @default.
- W3036217148 cites W2018853148 @default.
- W3036217148 cites W2019470807 @default.
- W3036217148 cites W2032084596 @default.
- W3036217148 cites W2036110852 @default.
- W3036217148 cites W2036364175 @default.
- W3036217148 cites W2036615909 @default.
- W3036217148 cites W2037791269 @default.
- W3036217148 cites W2038352605 @default.
- W3036217148 cites W2042163600 @default.
- W3036217148 cites W2047454304 @default.
- W3036217148 cites W2047683813 @default.
- W3036217148 cites W2055754263 @default.
- W3036217148 cites W2058199811 @default.
- W3036217148 cites W2059544030 @default.
- W3036217148 cites W2061670885 @default.
- W3036217148 cites W2062631853 @default.
- W3036217148 cites W2068456197 @default.
- W3036217148 cites W2068540155 @default.
- W3036217148 cites W2072746629 @default.
- W3036217148 cites W2077064497 @default.
- W3036217148 cites W2082289092 @default.
- W3036217148 cites W2082398972 @default.
- W3036217148 cites W2095233738 @default.
- W3036217148 cites W2098358427 @default.
- W3036217148 cites W2100943142 @default.
- W3036217148 cites W2103675516 @default.
- W3036217148 cites W2106487699 @default.
- W3036217148 cites W2108745700 @default.
- W3036217148 cites W2109558666 @default.
- W3036217148 cites W2109948781 @default.
- W3036217148 cites W2119637518 @default.
- W3036217148 cites W2119781626 @default.
- W3036217148 cites W2120131517 @default.
- W3036217148 cites W2121100266 @default.
- W3036217148 cites W2121204029 @default.
- W3036217148 cites W2126077601 @default.
- W3036217148 cites W2127332827 @default.
- W3036217148 cites W2128478608 @default.
- W3036217148 cites W2129225495 @default.
- W3036217148 cites W2130239194 @default.
- W3036217148 cites W2131238971 @default.
- W3036217148 cites W2136983583 @default.
- W3036217148 cites W2140071252 @default.
- W3036217148 cites W2140906896 @default.
- W3036217148 cites W2146364623 @default.
- W3036217148 cites W2155952642 @default.
- W3036217148 cites W2156361406 @default.
- W3036217148 cites W2157013283 @default.
- W3036217148 cites W2157787094 @default.
- W3036217148 cites W2158010257 @default.
- W3036217148 cites W2159913632 @default.
- W3036217148 cites W2160251030 @default.
- W3036217148 cites W2165796896 @default.
- W3036217148 cites W2165964270 @default.
- W3036217148 cites W2166746630 @default.
- W3036217148 cites W2168016794 @default.
- W3036217148 cites W2170414517 @default.
- W3036217148 cites W2171929498 @default.
- W3036217148 cites W2186218348 @default.
- W3036217148 cites W2253261722 @default.
- W3036217148 cites W2268893908 @default.
- W3036217148 cites W2293112567 @default.
- W3036217148 cites W2295931084 @default.
- W3036217148 cites W2326139633 @default.
- W3036217148 cites W2327135216 @default.
- W3036217148 cites W2330278731 @default.
- W3036217148 cites W2340936863 @default.