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• W3036220960 endingPage "377" @default.
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• W3036220960 abstract "Vascular malformations occur during early vascular development resulting in abnormally formed vessels that can manifest as arterial, venous, capillary or lymphatic lesions, or in combination, and include local tissue overdevelopment. Vascular malformations are largely caused by sporadic somatic gene mutations. This article aims to review and discuss current molecular signaling pathways and therapeutic targets for vascular malformations and to classify vascular malformations according to the molecular pathways involved. A literature review was performed using Embase and Medline. Different MeSH terms were combined for the search strategy, with the aim of encompassing all studies describing the classification, pathogenesis, and treatment of vascular malformations. Major pathways involved in the pathogenesis of vascular malformations are vascular endothelial growth factor (VEGF), Ras/Raf/MEK/ERK, angiopoietin-TIE2, transforming growth factor beta (TGF-β), and PI3K/AKT/mTOR. These pathways are involved in controlling cellular growth, apoptosis, differentiation, and proliferation, and play a central role in endothelial cell signaling and angiogenesis. Many vascular malformations share similar aberrant molecular signaling pathways with cancers and inflammatory disorders. Therefore, selective anticancer agents and immunosuppressants may be beneficial in treating vascular malformations of specific mutations. The current classification systems of vascular malformations, including the International Society of the Study of Vascular Anomalies (ISSVA) classification, are primarily observational and clinical, and are not based on the molecular pathways involved in the pathogenesis of the condition. Several molecular pathways with potential therapeutic targets have been demonstrated to contribute to the development of various vascular anomalies. Classifying vascular malformations based on their molecular pathogenesis may improve treatment by determining the underlying nature of the condition and their potential therapeutic target." @default.
• W3036220960 created "2020-06-25" @default.
• W3036220960 creator A5064877301 @default.
• W3036220960 creator A5075430054 @default.
• W3036220960 creator A5076808555 @default.
• W3036220960 creator A5077725238 @default.
• W3036220960 creator A5085770549 @default.
• W3036220960 date "2020-06-22" @default.
• W3036220960 modified "2023-10-12" @default.
• W3036220960 title "Emerging importance of molecular pathogenesis of vascular malformations in clinical practice and classifications" @default.
• W3036220960 cites W1528120845 @default.
• W3036220960 cites W1538404912 @default.
• W3036220960 cites W1600324901 @default.
• W3036220960 cites W1672179546 @default.
• W3036220960 cites W1770121422 @default.
• W3036220960 cites W1861297546 @default.
• W3036220960 cites W1897008550 @default.
• W3036220960 cites W1914715397 @default.
• W3036220960 cites W1957871175 @default.
• W3036220960 cites W1966561876 @default.
• W3036220960 cites W1968215541 @default.
• W3036220960 cites W1970138620 @default.
• W3036220960 cites W1970614272 @default.
• W3036220960 cites W1973376683 @default.
• W3036220960 cites W1973591203 @default.
• W3036220960 cites W1978572651 @default.
• W3036220960 cites W1978999523 @default.
• W3036220960 cites W1985712533 @default.
• W3036220960 cites W1985804036 @default.
• W3036220960 cites W1988613013 @default.
• W3036220960 cites W1990275904 @default.
• W3036220960 cites W1994904738 @default.
• W3036220960 cites W1996274397 @default.
• W3036220960 cites W1997620556 @default.
• W3036220960 cites W2000133490 @default.
• W3036220960 cites W2000239178 @default.
• W3036220960 cites W2001658518 @default.
• W3036220960 cites W2003598961 @default.
• W3036220960 cites W2008416056 @default.
• W3036220960 cites W2008607458 @default.
• W3036220960 cites W2009240587 @default.
• W3036220960 cites W2010704730 @default.
• W3036220960 cites W2014031706 @default.
• W3036220960 cites W2017352211 @default.
• W3036220960 cites W2017739035 @default.
• W3036220960 cites W2020585727 @default.
• W3036220960 cites W2020931266 @default.
• W3036220960 cites W2021806197 @default.
• W3036220960 cites W2023453327 @default.
• W3036220960 cites W2027052842 @default.
• W3036220960 cites W2027651950 @default.
• W3036220960 cites W2028846086 @default.
• W3036220960 cites W2030970153 @default.
• W3036220960 cites W2033002143 @default.
• W3036220960 cites W2033169004 @default.
• W3036220960 cites W2038039729 @default.
• W3036220960 cites W2040089666 @default.
• W3036220960 cites W2043982166 @default.
• W3036220960 cites W2045247659 @default.
• W3036220960 cites W2046052619 @default.
• W3036220960 cites W2046744395 @default.
• W3036220960 cites W2048407117 @default.
• W3036220960 cites W2050070176 @default.
• W3036220960 cites W2053354955 @default.
• W3036220960 cites W2056769082 @default.
• W3036220960 cites W2060372234 @default.
• W3036220960 cites W2063787079 @default.
• W3036220960 cites W2064739543 @default.
• W3036220960 cites W2069469997 @default.
• W3036220960 cites W2071628605 @default.
• W3036220960 cites W2075082022 @default.
• W3036220960 cites W2075998623 @default.
• W3036220960 cites W2076222956 @default.
• W3036220960 cites W2081236313 @default.
• W3036220960 cites W2082711484 @default.
• W3036220960 cites W2084161539 @default.
• W3036220960 cites W2092559291 @default.
• W3036220960 cites W2093316809 @default.
• W3036220960 cites W2098946934 @default.
• W3036220960 cites W2103823463 @default.
• W3036220960 cites W2108356703 @default.
• W3036220960 cites W2110109000 @default.
• W3036220960 cites W2120014985 @default.
• W3036220960 cites W2120154503 @default.
• W3036220960 cites W2127776747 @default.
• W3036220960 cites W2127959493 @default.
• W3036220960 cites W2130139387 @default.
• W3036220960 cites W2130685621 @default.
• W3036220960 cites W2131246162 @default.
• W3036220960 cites W2135935074 @default.
• W3036220960 cites W2140265740 @default.
• W3036220960 cites W2143053829 @default.
• W3036220960 cites W2147941657 @default.
• W3036220960 cites W2152215024 @default.
• W3036220960 cites W2152811972 @default.
• W3036220960 cites W2155495006 @default.
• W3036220960 cites W2159139124 @default.
• W3036220960 cites W2161975892 @default.

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