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- W3036223894 abstract "Abstract Imatinib mesylate is a tyrosine kinase inhibitor and used as the first-line medication for chronic myeloid leukaemia. Herein, we report two rare cases of hyperpigmentation of the palatal mucosa associated with imatinib mesylate therapy to treat chronic myeloid leukaemia in patients of Chinese ethnicity. A diffuse, bluish-grey lesion located on the hard palate was observed in both patients, and incisional biopsies were performed. Histopathological findings showed deposition of melanin pigments within the lamina propria with no increased melanocytes numbers within epithelium and lamina propria. The histopathologic findings and clinical history were consistent with the diagnosis of drug-induced oral melanosis. Clinicians should be cognizant that hyperpigmentation of the palatal mucosa is a rare side effect of imatinib mesylate therapy and include it as a possible differential diagnosis in oral melanosis cases." @default.
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- W3036223894 date "2020-09-01" @default.
- W3036223894 modified "2023-09-24" @default.
- W3036223894 title "Palatal hyperpigmentation associated with imatinib mesylate: Two cases of Chinese ethnicity" @default.
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- W3036223894 doi "https://doi.org/10.1016/j.ajoms.2020.05.002" @default.
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