FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036227265> ?p ?o ?g. }

• W3036227265 endingPage "245024" @default.
• W3036227265 startingPage "245024" @default.
• W3036227265 abstract "Relative biological effectiveness (RBE) variations are thought to be one of the primary causes of unexpected normal-tissue toxicities during tumor treatments with charged particles. Unlike carbon therapy, where treatment planning is optimized on the basis of the RBE-weighted dose, a constant RBE value of 1.1 is currently used in proton therapy. Assuming a uniform value can lead to under- or over-dosage, not just to the tumor but also to surrounding normal tissue. RBE changes have been linked with dose/fraction, the biological endpoint and beam properties. Understanding radiation quality and the associated RBE can improve the prediction of normal-tissue toxicities. In this study, we exploited microdosimetry for characterizing radiation quality in proton therapy in-field, and off-beam at 20 (beam edge), 50 (close out-of-field) and 100 (far out-of-field) mm from the beam center. We measured the lineal energy y spectra in a water phantom irradiated with 152 MeV protons, from which beam quality as well as the physical dose could be obtained. Taking advantage of the linear quadratic model and a modified version of the microdosimetric kinetic model, the microdosimetric data were combined with radiobiological parameters (α and β) of human salivary gland tumor cells for assessing cell survival RBE and RBE-weighted dose. The results indicate that if a dose of 60 Gy is delivered to the peak, the beam edge receives up to 6 Gy while the close and far out-of-field regions receive doses on the order of 10-3 Gy and 10-4 Gy, respectively. The RBE estimate in-beam shows large variations, ranging from 1.0 ± 0.2 at the entrance channel to 2.51 ± 0.15 at the tail. The beam edge follows a similar trend but the RBE calculated at the Bragg peak depth is 2.27 ± 0.17, i.e. twice the RBE in-beam (1.05 ± 0.15). Out-of-field, the estimated RBE is always significantly higher than 1.1 and increases with increasing lateral distance, reaching the overall highest value of 3.4 ± 0.3 at a depth of 206 mm and a lateral distance of 10 mm. The combination of RBE and dose into the biological dose points to the beam edge and the end-of-range in-beam as the areas with the highest risk of potential toxicities." @default.
• W3036227265 created "2020-06-25" @default.
• W3036227265 creator A5000666911 @default.
• W3036227265 creator A5001289924 @default.
• W3036227265 creator A5022067312 @default.
• W3036227265 creator A5023618347 @default.
• W3036227265 creator A5034267847 @default.
• W3036227265 creator A5036187834 @default.
• W3036227265 creator A5063338997 @default.
• W3036227265 creator A5064520298 @default.
• W3036227265 date "2020-12-17" @default.
• W3036227265 modified "2023-10-14" @default.
• W3036227265 title "Microdosimetric measurements as a tool to assess potential in-field and out-of-field toxicity regions in proton therapy" @default.
• W3036227265 cites W1232902676 @default.
• W3036227265 cites W1735419740 @default.
• W3036227265 cites W1996353985 @default.
• W3036227265 cites W1998242258 @default.
• W3036227265 cites W2005775826 @default.
• W3036227265 cites W2007665989 @default.
• W3036227265 cites W2014481731 @default.
• W3036227265 cites W2018009019 @default.
• W3036227265 cites W2030544564 @default.
• W3036227265 cites W2040145532 @default.
• W3036227265 cites W2040992522 @default.
• W3036227265 cites W2061728374 @default.
• W3036227265 cites W2083770395 @default.
• W3036227265 cites W2088348443 @default.
• W3036227265 cites W2088413560 @default.
• W3036227265 cites W2091705392 @default.
• W3036227265 cites W2094691048 @default.
• W3036227265 cites W2099370920 @default.
• W3036227265 cites W2104358865 @default.
• W3036227265 cites W2117181072 @default.
• W3036227265 cites W2119238049 @default.
• W3036227265 cites W2160440514 @default.
• W3036227265 cites W2162376301 @default.
• W3036227265 cites W2509332681 @default.
• W3036227265 cites W2513819086 @default.
• W3036227265 cites W2604998704 @default.
• W3036227265 cites W2619871745 @default.
• W3036227265 cites W2656937368 @default.
• W3036227265 cites W2734489913 @default.
• W3036227265 cites W2750680619 @default.
• W3036227265 cites W2765199874 @default.
• W3036227265 cites W2794514924 @default.
• W3036227265 cites W2800649452 @default.
• W3036227265 cites W2883407813 @default.
• W3036227265 cites W2889949812 @default.
• W3036227265 cites W2891092001 @default.
• W3036227265 cites W2896965491 @default.
• W3036227265 cites W2901526222 @default.
• W3036227265 cites W2902315799 @default.
• W3036227265 cites W2903840723 @default.
• W3036227265 cites W2912071408 @default.
• W3036227265 cites W2912750072 @default.
• W3036227265 cites W2917971697 @default.
• W3036227265 cites W2946734468 @default.
• W3036227265 cites W2947375096 @default.
• W3036227265 cites W2958451406 @default.
• W3036227265 cites W2960533539 @default.
• W3036227265 cites W3123932749 @default.
• W3036227265 cites W4248473228 @default.
• W3036227265 cites W4251243716 @default.
• W3036227265 cites W4254119409 @default.
• W3036227265 doi "https://doi.org/10.1088/1361-6560/ab9e56" @default.
• W3036227265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32554886" @default.
• W3036227265 hasPublicationYear "2020" @default.
• W3036227265 type Work @default.
• W3036227265 sameAs 3036227265 @default.
• W3036227265 citedByCount "11" @default.
• W3036227265 countsByYear W30362272652020 @default.
• W3036227265 countsByYear W30362272652021 @default.
• W3036227265 countsByYear W30362272652022 @default.
• W3036227265 countsByYear W30362272652023 @default.
• W3036227265 crossrefType "journal-article" @default.
• W3036227265 hasAuthorship W3036227265A5000666911 @default.
• W3036227265 hasAuthorship W3036227265A5001289924 @default.
• W3036227265 hasAuthorship W3036227265A5022067312 @default.
• W3036227265 hasAuthorship W3036227265A5023618347 @default.
• W3036227265 hasAuthorship W3036227265A5034267847 @default.
• W3036227265 hasAuthorship W3036227265A5036187834 @default.
• W3036227265 hasAuthorship W3036227265A5063338997 @default.
• W3036227265 hasAuthorship W3036227265A5064520298 @default.
• W3036227265 hasConcept C104293457 @default.
• W3036227265 hasConcept C111337013 @default.
• W3036227265 hasConcept C11928243 @default.
• W3036227265 hasConcept C120665830 @default.
• W3036227265 hasConcept C121332964 @default.
• W3036227265 hasConcept C126838900 @default.
• W3036227265 hasConcept C168834538 @default.
• W3036227265 hasConcept C185544564 @default.
• W3036227265 hasConcept C2779244869 @default.
• W3036227265 hasConcept C2989005 @default.
• W3036227265 hasConcept C509974204 @default.
• W3036227265 hasConcept C54516573 @default.
• W3036227265 hasConcept C71924100 @default.
• W3036227265 hasConcept C86611320 @default.
• W3036227265 hasConceptScore W3036227265C104293457 @default.

• next