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• W3036248974 abstract "Purpose To evaluate the value of quantitative parameters derived from dual-energy computed tomography (DECT) in assessing the aggressiveness of rectal cancer. Materials and methods Seventy-eight patients with rectal cancers confirmed by pathology underwent contrasted DECT scans. The normalized iodine concentration (NIC) and normalized water concentration (NWC) of the tumor against artery and tumor sizes were measured. The quantitative parameters were compared and statistically analyzed between subgroups based on the following prognostic factors: pretreatment carcinoembryonic antigen (CEA) levels, mesorectal fascia (MRF) status, T stage (T1,2 and T3,4), N stage (N0 and N1,2), tumor differentiation grade (poor differentiation, poor-moderate differentiation, moderate differentiation, moderate-well differentiation, well differentiation), and extramural venous invasion. Results The differences of NIC values between MRF-free and MRF-invaded groups (P = 0.042), between T2 and T3–4 stage groups (P = 0.044), between N0 and N+ (N1, 2) groups (P = 0.036), between poor differentiation group and other differentiated groups (P < 0.05)were respectively significant. No significant differences of NIC values existed between CEA level or extramural venous invasion subgroups. For NWC values and tumor sizes, there were no significant differences between subgroups based on the prognostic factors above all. Conclusions Higher NIC value is associated with a more aggressive tumor character. NIC value may have the potential to become an imaging biomarker of tumor aggressiveness." @default.
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• W3036248974 date "2020-12-01" @default.
• W3036248974 modified "2023-09-27" @default.
• W3036248974 title "Assessment of the aggressiveness of rectal cancer using quantitative parameters derived from dual-energy computed tomography" @default.
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• W3036248974 doi "https://doi.org/10.1016/j.clinimag.2020.06.028" @default.
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