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- W3036279382 abstract "Chronic pruritus significantly impacts quality of life and is a unifying symptom in patients with the inflammatory skin diseases bullous pemphigoid (BP) and atopic dermatitis (AD). Limited data are available related to neurophysiologic mechanisms underlying both pruritic conditions. Five patients with BP (n=2) or AD (n=3) were followed over a 6-month period while receiving treatment. Disease severity was calculated with the BP Disease Area Index for BP patients or the Eczema Area and Severity Index (EASI) and SCORing Atopic Dermatitis (SCORAD) for AD patients. Itch intensity was measured using the ItchyQuant self-reported pruritus severity scale. Alterations in intraepidermal nerve fiber density (IENFD) were compared between BP patients, AD patients, and healthy controls (HC) (n=7). Severity scores for patients at baseline ranged from: 11-24 (BPDAI), 0-7.4 (EASI) and 14.91-62.16 (SCORAD). Itch intensity was not altered between baseline and 6-month follow-up (mean 5.2 at both time points). Both AD and BP demonstrated a decreased IENFD compared with HC (AD 4.04 fibers/mm, BP 6.95 fibers/mm, HC 9.34 fibers/mm) at baseline. While there was no significant difference between IENFD in AD and BP at baseline, there was a significant increase in IENFD in both conditions noted at 6-month follow-up, respectively (AD 4.0 fibers/mm, BP 6.9 fibers/mm vs AD 7.4 fibers/mm, BP 11.9 fibers/mm, p=0.002). These findings suggest that neuroanatomical alterations of epidermal nerve fibers seen in chronic pruritus may be a common phenomenon in seemingly divergent inflammatory skin diseases and reversible with appropriate treatment. Future studies to elucidate mechanistic details related to changes in IENFD may inform potential novel therapeutics." @default.
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- W3036279382 date "2020-07-01" @default.
- W3036279382 modified "2023-09-26" @default.
- W3036279382 title "176 Comparative analysis of pruritus and intraepidermal nerve fiber density in atopic dermatitis and bullous pemphigoid" @default.
- W3036279382 doi "https://doi.org/10.1016/j.jid.2020.03.180" @default.
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