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- W3036291377 abstract "Abstract Racemic ethyl 2,3‐dibromopropionate, commercially available at low price, is a key intermediate used in the synthesis of several heterocycle fragments, which are present in many biologically active compounds. Surprisingly, the enantiomers are not commercially available and have never been described in the literature. In this work, we undertook two different strategies to obtain these enantiomers, which are enantioselective synthesis and preparative HPLC enantioseparation of commercially available racemate on multigram scale. The first strategy has proved inadequate because racemization occurred during the synthesis (ee ≈ 9‐50%). Conversely, the second strategy produced a very good enantioseparation of commercially available racemate (ee > 99.5% for both enantiomers) on multigram scale." @default.
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- W3036291377 date "2020-06-22" @default.
- W3036291377 modified "2023-10-13" @default.
- W3036291377 title "Enantiopure ethyl 2,3‐dibromopropionate: Enantioselective synthesis <i>vs</i> preparative HPLC enantioseparation of racemate on multigram scale" @default.
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- W3036291377 doi "https://doi.org/10.1002/chir.23260" @default.
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