Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036344565> ?p ?o ?g. }
- W3036344565 abstract "Mantle cell lymphoma (MCL) is a rare, B cell non-Hodgkin's lymphoma with highly heterogeneous clinical presentation and aggressiveness. First-line treatment consists of intensive chemotherapy with autologous stem cell transplant for the fit, transplant eligible patients, or less intensive chemotherapy for the less fit (and transplant-ineligible) patients. Patients eventually relapse with a progressive clinical course. Numerous therapeutic approaches have emerged over the last few years which have significantly changed the treatment landscape of MCL. These therapies consist of targeted approaches such as BTK and BCL2 inhibitors that provide durable therapeutic responses. However, the optimum combination and sequencing of these therapies is unclear and is currently investigated in several ongoing studies. Furthermore, cellular therapies such as chimeric antigen receptor (CAR) T cells and bispecific T cell engager (BiTe) antibodies have shown impressive results and will likely shape treatment approaches in relapsed MCL, especially after failure with BTK inhibitors. Herein, we provide a comprehensive review of past and ongoing studies that will likely significantly impact our approach to MCL treatment in both the frontline (for transplant eligible and ineligible patients) as well as in the relapsed setting. We present the most up to date results from these studies as well as perspectives on future studies in MCL." @default.
- W3036344565 created "2020-06-25" @default.
- W3036344565 creator A5045749472 @default.
- W3036344565 creator A5085565650 @default.
- W3036344565 date "2020-06-17" @default.
- W3036344565 modified "2023-10-13" @default.
- W3036344565 title "Emerging therapies in mantle cell lymphoma" @default.
- W3036344565 cites W1829587101 @default.
- W3036344565 cites W1974084203 @default.
- W3036344565 cites W1990310737 @default.
- W3036344565 cites W199065211 @default.
- W3036344565 cites W1993827508 @default.
- W3036344565 cites W1999824748 @default.
- W3036344565 cites W2000302977 @default.
- W3036344565 cites W2007185019 @default.
- W3036344565 cites W2010753128 @default.
- W3036344565 cites W2020362172 @default.
- W3036344565 cites W2029117730 @default.
- W3036344565 cites W2029664590 @default.
- W3036344565 cites W2030263904 @default.
- W3036344565 cites W2044348066 @default.
- W3036344565 cites W2055352702 @default.
- W3036344565 cites W2062911024 @default.
- W3036344565 cites W2063779563 @default.
- W3036344565 cites W2065464657 @default.
- W3036344565 cites W2078761761 @default.
- W3036344565 cites W2095669071 @default.
- W3036344565 cites W2098002594 @default.
- W3036344565 cites W2099348990 @default.
- W3036344565 cites W2100645234 @default.
- W3036344565 cites W2104235597 @default.
- W3036344565 cites W2106904404 @default.
- W3036344565 cites W2107071884 @default.
- W3036344565 cites W2111611512 @default.
- W3036344565 cites W2116090592 @default.
- W3036344565 cites W2130669641 @default.
- W3036344565 cites W2136905052 @default.
- W3036344565 cites W2143901303 @default.
- W3036344565 cites W2147422161 @default.
- W3036344565 cites W2150992964 @default.
- W3036344565 cites W2152146977 @default.
- W3036344565 cites W2164825132 @default.
- W3036344565 cites W2165571903 @default.
- W3036344565 cites W2184668473 @default.
- W3036344565 cites W2187899653 @default.
- W3036344565 cites W2190884983 @default.
- W3036344565 cites W2210752542 @default.
- W3036344565 cites W2237195636 @default.
- W3036344565 cites W2279127916 @default.
- W3036344565 cites W2287519522 @default.
- W3036344565 cites W2296618733 @default.
- W3036344565 cites W2305782972 @default.
- W3036344565 cites W2308395117 @default.
- W3036344565 cites W2310716991 @default.
- W3036344565 cites W2325329618 @default.
- W3036344565 cites W2460527563 @default.
- W3036344565 cites W2529212447 @default.
- W3036344565 cites W2556491571 @default.
- W3036344565 cites W2557693560 @default.
- W3036344565 cites W2569849048 @default.
- W3036344565 cites W2572272770 @default.
- W3036344565 cites W2575001609 @default.
- W3036344565 cites W2582696216 @default.
- W3036344565 cites W2583916346 @default.
- W3036344565 cites W2597800737 @default.
- W3036344565 cites W2600359049 @default.
- W3036344565 cites W2609037652 @default.
- W3036344565 cites W2725925241 @default.
- W3036344565 cites W2734526350 @default.
- W3036344565 cites W2748428998 @default.
- W3036344565 cites W2749289906 @default.
- W3036344565 cites W2772285283 @default.
- W3036344565 cites W2773804840 @default.
- W3036344565 cites W2774522106 @default.
- W3036344565 cites W2787370436 @default.
- W3036344565 cites W2789814657 @default.
- W3036344565 cites W2789949637 @default.
- W3036344565 cites W2791236038 @default.
- W3036344565 cites W2791299132 @default.
- W3036344565 cites W2795301499 @default.
- W3036344565 cites W2800949131 @default.
- W3036344565 cites W2802488013 @default.
- W3036344565 cites W2806532541 @default.
- W3036344565 cites W2810600203 @default.
- W3036344565 cites W2883570202 @default.
- W3036344565 cites W2885382985 @default.
- W3036344565 cites W2886450418 @default.
- W3036344565 cites W2890354015 @default.
- W3036344565 cites W2891543930 @default.
- W3036344565 cites W2892160172 @default.
- W3036344565 cites W2902758837 @default.
- W3036344565 cites W2903062212 @default.
- W3036344565 cites W2906765096 @default.
- W3036344565 cites W2906983378 @default.
- W3036344565 cites W2907057265 @default.
- W3036344565 cites W2907337505 @default.
- W3036344565 cites W2910871809 @default.
- W3036344565 cites W2911954503 @default.
- W3036344565 cites W2914400539 @default.
- W3036344565 cites W2914575774 @default.