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- W3036366907 endingPage "100866" @default.
- W3036366907 startingPage "100866" @default.
- W3036366907 abstract "Iron is a constituent of many metalloproteins involved in vital metabolic functions. While adequate iron supply is critical for health, accumulation of excess iron promotes oxidative stress and causes tissue injury and disease. Therefore, iron homeostasis needs to be tightly controlled. Mammals have developed elegant homeostatic mechanisms at the cellular and systemic level, which serve to satisfy metabolic needs for iron and to minimize the risks posed by iron's toxicity. Cellular iron metabolism is post-transcriptionally controlled by iron regulatory proteins, IRP1 and IRP2, while systemic iron balance is regulated by the iron hormone hepcidin. This review summarizes basic principles of mammalian iron homeostasis at the cellular and systemic level. Particular attention is given on pathways for hepcidin regulation and on crosstalk between cellular and systemic homeostatic mechanisms." @default.
- W3036366907 created "2020-06-25" @default.
- W3036366907 creator A5023025618 @default.
- W3036366907 creator A5068254191 @default.
- W3036366907 date "2020-10-01" @default.
- W3036366907 modified "2023-10-03" @default.
- W3036366907 title "Basics and principles of cellular and systemic iron homeostasis" @default.
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- W3036366907 cites W1838017855 @default.
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- W3036366907 cites W1980042430 @default.
- W3036366907 cites W1987535606 @default.
- W3036366907 cites W1997225537 @default.
- W3036366907 cites W1997734311 @default.
- W3036366907 cites W2002227779 @default.
- W3036366907 cites W2005664965 @default.
- W3036366907 cites W2006046265 @default.
- W3036366907 cites W2024148446 @default.
- W3036366907 cites W2027090078 @default.
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- W3036366907 cites W2053312128 @default.
- W3036366907 cites W2072829138 @default.
- W3036366907 cites W2082038436 @default.
- W3036366907 cites W2082341124 @default.
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- W3036366907 doi "https://doi.org/10.1016/j.mam.2020.100866" @default.
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