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• W3036370955 abstract "• Lachancea thermotolerans strains display a huge diversity in lactic acid production. • Whole-genome sequences of high and low lactic acid producer strains were obtained. • Sequences of key genes for lactic acid accumulation were aligned and scrutinised. • Differences in promoters and transcription factor binding sites were highlighted. • Gene expression analysis revealed dissimilarities in the transcription of the genes ldh . Non-conventional yeasts are increasingly applied in fermented beverage industry to obtain distinctive products with improved quality. Among these yeasts, Lachancea thermotolerans has multiple features of industrial relevance, especially the production of l (+)-lactic acid (LA), useful for the biological acidification of wine and beer. Since few information is available on this peculiar activity, the current study aimed to explore the physiological and genetic variability among L. thermotolerans strains. From a strain collection, mostly isolated from wine, a huge phenotypic diversity was acknowledged and allowed the selection of a high (SOL13) and a low (COLC27) LA producer. Comparative whole-genome sequencing of these two selected strains and the type strain CBS 6340 T showed a high similarity in terms of gene content and functional annotation. Notwithstanding, target gene-based analysis revealed variations between high and low producers in the key gene sequences related to LA accumulation. More in-depth investigation of the core promoters and expression analysis of the genes ldh , encoding lactate dehydrogenase, indicated the transcriptional regulation may be the principal cause behind phenotypic differences. These findings highlighted the usefulness of whole-genome sequencing coupled with expression analysis. They provided crucial genetic insights for a deeper investigation of the intraspecific variability in LA production pathway." @default.
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• W3036370955 date "2020-09-01" @default.
• W3036370955 modified "2023-10-16" @default.
• W3036370955 title "New insights into the variability of lactic acid production in Lachancea thermotolerans at the phenotypic and genomic level" @default.
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• W3036370955 doi "https://doi.org/10.1016/j.micres.2020.126525" @default.
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