Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036405021> ?p ?o ?g. }
- W3036405021 endingPage "863" @default.
- W3036405021 startingPage "853" @default.
- W3036405021 abstract "Abstract Clear cell renal cell carcinoma (ccRCC) is a common malignancy of the genitourinary system and is associated with high mortality rates. However, the molecular mechanism of ccRCC pathogenesis is still unclear, which translates to few effective diagnostic and prognostic biomarkers. In this study, we conducted a bioinformatics analysis on three Gene Expression Omnibus datasets and identified 437 differentially expressed genes (DEGs) related to ccRCC development and prognosis, of which 311 and 126 genes are respectively down-regulated and up-regulated. The protein–protein interaction network of these DEGs consists of 395 nodes and 1872 interactions and 2 prominent modules. The Staphylococcus aureus infection and complement and coagulation cascades are significantly enriched in module 1 and are likely involved in ccRCC progression. Forty-two hub genes were screened, of which von Willebrand factor, TIMP metallopeptidase inhibitor 1, plasminogen, formimidoyltransferase cyclodeaminase, solute carrier family 34 member 1, hydroxyacid oxidase 2, alanine-glyoxylate aminotransferase 2, phosphoenolpyruvate carboxykinase 1, and 3-hydroxy-3-methylglutaryl-CoA synthase 2 are possibly related to the prognosis of ccRCC. The differential expression of all nine genes was confirmed by quantitative real-time polymerase chain reaction analysis of the ccRCC and normal renal tissues. These key genes are potential biomarkers for the diagnosis and prognosis of ccRCC and warrant further investigation." @default.
- W3036405021 created "2020-06-25" @default.
- W3036405021 creator A5014096233 @default.
- W3036405021 creator A5026972252 @default.
- W3036405021 creator A5037163346 @default.
- W3036405021 creator A5065018805 @default.
- W3036405021 creator A5087795416 @default.
- W3036405021 date "2020-06-01" @default.
- W3036405021 modified "2023-10-18" @default.
- W3036405021 title "Identification of potential key genes and key pathways related to clear cell renal cell carcinoma through bioinformatics analysis" @default.
- W3036405021 cites W1976043651 @default.
- W3036405021 cites W1977845140 @default.
- W3036405021 cites W1985213644 @default.
- W3036405021 cites W2092288031 @default.
- W3036405021 cites W2097795961 @default.
- W3036405021 cites W2100239923 @default.
- W3036405021 cites W2103912979 @default.
- W3036405021 cites W2106391842 @default.
- W3036405021 cites W2118258530 @default.
- W3036405021 cites W2143013757 @default.
- W3036405021 cites W2146512944 @default.
- W3036405021 cites W2159675211 @default.
- W3036405021 cites W2160478953 @default.
- W3036405021 cites W2162911482 @default.
- W3036405021 cites W2163576489 @default.
- W3036405021 cites W2169688641 @default.
- W3036405021 cites W2345356016 @default.
- W3036405021 cites W2409323315 @default.
- W3036405021 cites W2466307295 @default.
- W3036405021 cites W2510079645 @default.
- W3036405021 cites W2514105479 @default.
- W3036405021 cites W2529946249 @default.
- W3036405021 cites W2532020496 @default.
- W3036405021 cites W2564283772 @default.
- W3036405021 cites W2596811519 @default.
- W3036405021 cites W2607129810 @default.
- W3036405021 cites W2751089373 @default.
- W3036405021 cites W2752053733 @default.
- W3036405021 cites W2765762941 @default.
- W3036405021 cites W2791414104 @default.
- W3036405021 cites W2796207353 @default.
- W3036405021 cites W2799562872 @default.
- W3036405021 cites W2802759810 @default.
- W3036405021 cites W2804422202 @default.
- W3036405021 cites W2884170377 @default.
- W3036405021 cites W2884346986 @default.
- W3036405021 cites W2890106399 @default.
- W3036405021 cites W2907709130 @default.
- W3036405021 cites W2911244069 @default.
- W3036405021 cites W2920864599 @default.
- W3036405021 cites W2921283762 @default.
- W3036405021 cites W2946226500 @default.
- W3036405021 cites W2946298884 @default.
- W3036405021 cites W2949707279 @default.
- W3036405021 cites W2967475808 @default.
- W3036405021 cites W2968696004 @default.
- W3036405021 cites W2971883356 @default.
- W3036405021 cites W2996686690 @default.
- W3036405021 doi "https://doi.org/10.1093/abbs/gmaa068" @default.
- W3036405021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32556097" @default.
- W3036405021 hasPublicationYear "2020" @default.
- W3036405021 type Work @default.
- W3036405021 sameAs 3036405021 @default.
- W3036405021 citedByCount "3" @default.
- W3036405021 countsByYear W30364050212020 @default.
- W3036405021 countsByYear W30364050212021 @default.
- W3036405021 countsByYear W30364050212022 @default.
- W3036405021 crossrefType "journal-article" @default.
- W3036405021 hasAuthorship W3036405021A5014096233 @default.
- W3036405021 hasAuthorship W3036405021A5026972252 @default.
- W3036405021 hasAuthorship W3036405021A5037163346 @default.
- W3036405021 hasAuthorship W3036405021A5065018805 @default.
- W3036405021 hasAuthorship W3036405021A5087795416 @default.
- W3036405021 hasConcept C104317684 @default.
- W3036405021 hasConcept C116834253 @default.
- W3036405021 hasConcept C143998085 @default.
- W3036405021 hasConcept C1491633281 @default.
- W3036405021 hasConcept C18903297 @default.
- W3036405021 hasConcept C26517878 @default.
- W3036405021 hasConcept C2777472916 @default.
- W3036405021 hasConcept C54355233 @default.
- W3036405021 hasConcept C59822182 @default.
- W3036405021 hasConcept C60644358 @default.
- W3036405021 hasConcept C70721500 @default.
- W3036405021 hasConcept C71924100 @default.
- W3036405021 hasConcept C86803240 @default.
- W3036405021 hasConceptScore W3036405021C104317684 @default.
- W3036405021 hasConceptScore W3036405021C116834253 @default.
- W3036405021 hasConceptScore W3036405021C143998085 @default.
- W3036405021 hasConceptScore W3036405021C1491633281 @default.
- W3036405021 hasConceptScore W3036405021C18903297 @default.
- W3036405021 hasConceptScore W3036405021C26517878 @default.
- W3036405021 hasConceptScore W3036405021C2777472916 @default.
- W3036405021 hasConceptScore W3036405021C54355233 @default.
- W3036405021 hasConceptScore W3036405021C59822182 @default.
- W3036405021 hasConceptScore W3036405021C60644358 @default.
- W3036405021 hasConceptScore W3036405021C70721500 @default.
- W3036405021 hasConceptScore W3036405021C71924100 @default.