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- W3036408312 abstract "Leprosy is one of the leading causes of preventable blindness in the world, yet It is largely ignored in blindness prevention programs. To date, little is known about the pathogenesis of ocular leprosy in humans. Histopathological studies have been necessarily 1imited to eyes removed at autopsy or enucleated from patients with advanced lepromatous leprosy. In an attempt to define the pathogenesis of the ocular complications of leprosy, we have studied the eyes of animal models namely, nine-banded armadillos with 1epromatous leprosy and injected Mycobacterium leprae ( M. leprae ) directly in the corneal stroma of armadillos. Fifty armadillos with experimental or naturally-acquired lepromatous leprosy were studied. Six armadillos were injected in the corneal stroma with 1 ul of an M. leprae suspension and examined two and four months later. Both eyes of each animal were enucleated at autopsy, fixed in paraformaldehyde-glutaraldehyde and processed for light and electron microscopy (EM). For light microscopy, the eyes were embedded in plastic methacrylate and sections stained with a modified acid-fast stain. For EM, tissues were post fixed in 1% OsO 4 dehydrated, and embedded in epon." @default.
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- W3036408312 date "1989-08-06" @default.
- W3036408312 modified "2023-10-16" @default.
- W3036408312 title "Transmission and Scanning Electron Microscopic studies of ocular leprosy in nine-banded armadillos" @default.
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- W3036408312 doi "https://doi.org/10.1017/s0424820100157176" @default.
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