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- W3036415929 endingPage "1503" @default.
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- W3036415929 abstract "Evolutionarily conserved Notch plays a critical role in embryonic development and cellular self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is widely described. Notch-activating mutations are associated with haematological malignancies and several solid tumours including breast, lung and adenoid cystic carcinoma. Moreover, upregulation of Notch receptors and ligands and aberrant Notch signalling is frequently observed in cancer. It is involved in cancer hallmarks including proliferation, survival, migration, angiogenesis, cancer stem cell renewal, metastasis and drug resistance. It is a key component of cell-to-cell interactions between cancer cells and cells of the tumour microenvironment, such as endothelial cells, immune cells and fibroblasts. Notch displays diverse crosstalk with many other oncogenic signalling pathways, and may drive acquired resistance to targeted therapies as well as resistance to standard chemo/radiation therapy. The past 10 years have seen the emergence of different classes of drugs therapeutically targeting Notch including receptor/ligand antibodies, gamma secretase inhibitors (GSI) and most recently, the development of Notch transcription complex inhibitors. It is an exciting time for Notch research with over 70 cancer clinical trials registered and the first-ever Phase III trial of a Notch GSI, nirogacestat, currently at the recruitment stage." @default.
- W3036415929 created "2020-06-25" @default.
- W3036415929 creator A5026949903 @default.
- W3036415929 creator A5071021600 @default.
- W3036415929 creator A5080850326 @default.
- W3036415929 creator A5086873593 @default.
- W3036415929 date "2020-06-20" @default.
- W3036415929 modified "2023-10-09" @default.
- W3036415929 title "Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives" @default.
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