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• W3036451600 abstract "Abstract In this study, we synthesized novel nitro quinolone‐based compounds and tested them in vitro against a panel of Gram‐positive and Gram‐negative pathogens including Mycobacterium tuberculosis (MTB), Pseudomonas aeruginosa , Acinetobacter baumannii , Klebsiella pneumonia , Staphylococcus aureus , and Escherichia coli for antibacterial activities and also against HeLa cells for overt cytotoxicity. Compound 8e was identified as a non‐toxic, potent hit with selective activity (MIC 90 ˂ 0.24 µ m ) against MTB. 8e , however, showed no activity against DprE1 mutant, suggesting DprE1 as the likely target for this compound class." @default.
• W3036451600 created "2020-06-25" @default.
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• W3036451600 date "2020-07-26" @default.
• W3036451600 modified "2023-10-18" @default.
• W3036451600 title "6‐Nitro‐1‐benzylquinolones exhibiting specific antitubercular activity" @default.
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• W3036451600 doi "https://doi.org/10.1111/cbdd.13747" @default.
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