Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036453600> ?p ?o ?g. }
- W3036453600 abstract "To understand the epidemiology and susceptibility patterns of yeast infections in Ontario, Canada, we examined 4,715 clinical yeast isolates submitted to our laboratory for antifungal susceptibility testing from 2014 to 2018. Candida albicans was the most frequently submitted species (43.0%), followed by C. glabrata (21.1%), C. parapsilosis (15.0%), and C. tropicalis (6.2%). Twenty-three other Candida spp. (11.6%) and 4 non-Candida species (3.1%) were also identified. Few changes in species distribution were observed from 2014 to 2018, but the total numbers of yeast isolates sent for testing increased, with an annual 7.4% change. According to CLSI clinical breakpoints, resistance rates remained low overall. Moderate fluconazole resistance was noted among C. glabrata (9%), C. parapsilosis (9%), and C. tropicalis (12%) isolates. Only 1% of C. glabrata isolates were resistant to caspofungin, micafungin, and anidulafungin. Whole-genome sequence analysis confirmed 11 cases of acquired resistance to azoles or echinocandins via in-host evolution. There were mutations in the gene for the catalytic subunit of 1,3-beta-glucan synthase-mediated echinocandin resistance in 3 of 3 C. albicans strains, 3 of 4 C. glabrata strains, and 1 strain of C. tropicalis Azole resistance was likely caused by a homozygous ERG3 mutation in 1 C. albicans strain and a previously undescribed chromosomal-duplication event involving ERG11 and TAC1 orthologs in 1 C. tropicalis strain. While antifungal resistance rates remain low among yeast isolates in Ontario, ongoing surveillance is necessary to inform empirical therapy for optimal patient management and to guide antifungal stewardship." @default.
- W3036453600 created "2020-06-25" @default.
- W3036453600 creator A5004604994 @default.
- W3036453600 creator A5021870371 @default.
- W3036453600 creator A5044724847 @default.
- W3036453600 creator A5044834575 @default.
- W3036453600 date "2020-08-20" @default.
- W3036453600 modified "2023-09-28" @default.
- W3036453600 title "Antifungal Susceptibility of Clinical Yeast Isolates from a Large Canadian Reference Laboratory and Application of Whole-Genome Sequence Analysis To Elucidate Mechanisms of Acquired Resistance" @default.
- W3036453600 cites W1508443003 @default.
- W3036453600 cites W1761128804 @default.
- W3036453600 cites W1800819261 @default.
- W3036453600 cites W1879723880 @default.
- W3036453600 cites W1915062133 @default.
- W3036453600 cites W1919257374 @default.
- W3036453600 cites W1942573227 @default.
- W3036453600 cites W1972692992 @default.
- W3036453600 cites W1984388269 @default.
- W3036453600 cites W1997594388 @default.
- W3036453600 cites W2019579326 @default.
- W3036453600 cites W2034450582 @default.
- W3036453600 cites W2044502735 @default.
- W3036453600 cites W2049505636 @default.
- W3036453600 cites W2053940732 @default.
- W3036453600 cites W2103441770 @default.
- W3036453600 cites W2106578986 @default.
- W3036453600 cites W2107090866 @default.
- W3036453600 cites W2107794472 @default.
- W3036453600 cites W2119180969 @default.
- W3036453600 cites W2121025359 @default.
- W3036453600 cites W2127535744 @default.
- W3036453600 cites W2128917111 @default.
- W3036453600 cites W2132284327 @default.
- W3036453600 cites W2135265373 @default.
- W3036453600 cites W2137015675 @default.
- W3036453600 cites W2145329735 @default.
- W3036453600 cites W2146485450 @default.
- W3036453600 cites W2162122300 @default.
- W3036453600 cites W2163061527 @default.
- W3036453600 cites W2163989602 @default.
- W3036453600 cites W2165158988 @default.
- W3036453600 cites W2167703450 @default.
- W3036453600 cites W2168133698 @default.
- W3036453600 cites W2169835699 @default.
- W3036453600 cites W2170770076 @default.
- W3036453600 cites W2171155970 @default.
- W3036453600 cites W2254445630 @default.
- W3036453600 cites W2276873560 @default.
- W3036453600 cites W2338633945 @default.
- W3036453600 cites W2516760155 @default.
- W3036453600 cites W2530772399 @default.
- W3036453600 cites W2551720400 @default.
- W3036453600 cites W2614979625 @default.
- W3036453600 cites W2617547222 @default.
- W3036453600 cites W2739674022 @default.
- W3036453600 cites W2745077547 @default.
- W3036453600 cites W2768076208 @default.
- W3036453600 cites W2769754674 @default.
- W3036453600 cites W2770095154 @default.
- W3036453600 cites W2773217499 @default.
- W3036453600 cites W2782394839 @default.
- W3036453600 cites W2799524357 @default.
- W3036453600 cites W2801270682 @default.
- W3036453600 cites W2891857259 @default.
- W3036453600 cites W2901497815 @default.
- W3036453600 cites W2902239651 @default.
- W3036453600 cites W2902287163 @default.
- W3036453600 cites W2903177545 @default.
- W3036453600 cites W2905604866 @default.
- W3036453600 cites W2906643351 @default.
- W3036453600 cites W2910178341 @default.
- W3036453600 cites W2910356989 @default.
- W3036453600 cites W2922388167 @default.
- W3036453600 cites W2951867871 @default.
- W3036453600 cites W2953431223 @default.
- W3036453600 cites W2955752975 @default.
- W3036453600 cites W2964743581 @default.
- W3036453600 cites W2966653318 @default.
- W3036453600 cites W2969566064 @default.
- W3036453600 doi "https://doi.org/10.1128/aac.00402-20" @default.
- W3036453600 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7449159" @default.
- W3036453600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32571812" @default.
- W3036453600 hasPublicationYear "2020" @default.
- W3036453600 type Work @default.
- W3036453600 sameAs 3036453600 @default.
- W3036453600 citedByCount "11" @default.
- W3036453600 countsByYear W30364536002021 @default.
- W3036453600 countsByYear W30364536002022 @default.
- W3036453600 countsByYear W30364536002023 @default.
- W3036453600 crossrefType "journal-article" @default.
- W3036453600 hasAuthorship W3036453600A5004604994 @default.
- W3036453600 hasAuthorship W3036453600A5021870371 @default.
- W3036453600 hasAuthorship W3036453600A5044724847 @default.
- W3036453600 hasAuthorship W3036453600A5044834575 @default.
- W3036453600 hasBestOaLocation W30364536002 @default.
- W3036453600 hasConcept C145081991 @default.
- W3036453600 hasConcept C2775835631 @default.
- W3036453600 hasConcept C2776222947 @default.
- W3036453600 hasConcept C2779020398 @default.
- W3036453600 hasConcept C2779320740 @default.