Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036476658> ?p ?o ?g. }
- W3036476658 endingPage "350" @default.
- W3036476658 startingPage "350" @default.
- W3036476658 abstract "A series of 2,4,5 trisubstituted-1,2,3-triazole analogues have been screened for their antifungal activity against five fungal strains, Candida parapsilosis, Candida albicans, Candida tropicalis, Aspergillus niger, and Trichophyton rubrum, via a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) microdilution assay. Compounds GKV10, GKV11, and GKV15 emerged as promising antifungal agents against all the fungal strains used in the current study. One of the highly active antifungal compounds, GKV10, was selected for a single-crystal X-ray diffraction analysis to unequivocally establish its molecular structure, conformation, and to understand the presence of different intermolecular interactions in its crystal lattice. A cooperative synergy of the C-H···O, C-H···N, C-H···S, C-H···π, and π···π intermolecular interactions was present in the crystal structure, which contributed towards the overall stabilization of the lattice. A molecular docking study was conducted for all the test compounds against Candida albicans lanosterol-14α-demethylase (pdb = 5 tzl). The binding stability of the highly promising antifungal test compound, GKV15, from the series was then evaluated by molecular dynamics studies." @default.
- W3036476658 created "2020-06-25" @default.
- W3036476658 creator A5001934184 @default.
- W3036476658 creator A5014070053 @default.
- W3036476658 creator A5015026936 @default.
- W3036476658 creator A5016589373 @default.
- W3036476658 creator A5027363854 @default.
- W3036476658 creator A5033516461 @default.
- W3036476658 creator A5040297048 @default.
- W3036476658 creator A5043847017 @default.
- W3036476658 creator A5044687882 @default.
- W3036476658 creator A5048041444 @default.
- W3036476658 creator A5053628572 @default.
- W3036476658 creator A5055445932 @default.
- W3036476658 creator A5066939276 @default.
- W3036476658 creator A5079955860 @default.
- W3036476658 creator A5085320315 @default.
- W3036476658 creator A5088959418 @default.
- W3036476658 creator A5089347460 @default.
- W3036476658 creator A5091621724 @default.
- W3036476658 date "2020-06-20" @default.
- W3036476658 modified "2023-09-26" @default.
- W3036476658 title "Crystallography, in Silico Studies, and In Vitro Antifungal Studies of 2,4,5 Trisubstituted 1,2,3-Triazole Analogues" @default.
- W3036476658 cites W1567464438 @default.
- W3036476658 cites W1901716435 @default.
- W3036476658 cites W1963612968 @default.
- W3036476658 cites W1971448184 @default.
- W3036476658 cites W1972493784 @default.
- W3036476658 cites W1979368277 @default.
- W3036476658 cites W2025346214 @default.
- W3036476658 cites W2035494685 @default.
- W3036476658 cites W2041902142 @default.
- W3036476658 cites W2052621833 @default.
- W3036476658 cites W2063334178 @default.
- W3036476658 cites W2064068872 @default.
- W3036476658 cites W2087501305 @default.
- W3036476658 cites W2095070414 @default.
- W3036476658 cites W2098202202 @default.
- W3036476658 cites W2104822689 @default.
- W3036476658 cites W2127019493 @default.
- W3036476658 cites W2127661659 @default.
- W3036476658 cites W2131350133 @default.
- W3036476658 cites W2145538332 @default.
- W3036476658 cites W2163470542 @default.
- W3036476658 cites W2284844091 @default.
- W3036476658 cites W2416913349 @default.
- W3036476658 cites W2513270693 @default.
- W3036476658 cites W2523192286 @default.
- W3036476658 cites W2583754905 @default.
- W3036476658 cites W2624949201 @default.
- W3036476658 cites W2732995536 @default.
- W3036476658 cites W2774006626 @default.
- W3036476658 cites W2801352359 @default.
- W3036476658 cites W2887488081 @default.
- W3036476658 cites W2890113888 @default.
- W3036476658 cites W2927963600 @default.
- W3036476658 cites W2948823581 @default.
- W3036476658 cites W2952740302 @default.
- W3036476658 cites W2952994273 @default.
- W3036476658 cites W2994249507 @default.
- W3036476658 cites W3010335444 @default.
- W3036476658 cites W3023379648 @default.
- W3036476658 cites W3023571643 @default.
- W3036476658 cites W4244971832 @default.
- W3036476658 doi "https://doi.org/10.3390/antibiotics9060350" @default.
- W3036476658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7344790" @default.
- W3036476658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32575727" @default.
- W3036476658 hasPublicationYear "2020" @default.
- W3036476658 type Work @default.
- W3036476658 sameAs 3036476658 @default.
- W3036476658 citedByCount "11" @default.
- W3036476658 countsByYear W30364766582020 @default.
- W3036476658 countsByYear W30364766582021 @default.
- W3036476658 countsByYear W30364766582022 @default.
- W3036476658 countsByYear W30364766582023 @default.
- W3036476658 crossrefType "journal-article" @default.
- W3036476658 hasAuthorship W3036476658A5001934184 @default.
- W3036476658 hasAuthorship W3036476658A5014070053 @default.
- W3036476658 hasAuthorship W3036476658A5015026936 @default.
- W3036476658 hasAuthorship W3036476658A5016589373 @default.
- W3036476658 hasAuthorship W3036476658A5027363854 @default.
- W3036476658 hasAuthorship W3036476658A5033516461 @default.
- W3036476658 hasAuthorship W3036476658A5040297048 @default.
- W3036476658 hasAuthorship W3036476658A5043847017 @default.
- W3036476658 hasAuthorship W3036476658A5044687882 @default.
- W3036476658 hasAuthorship W3036476658A5048041444 @default.
- W3036476658 hasAuthorship W3036476658A5053628572 @default.
- W3036476658 hasAuthorship W3036476658A5055445932 @default.
- W3036476658 hasAuthorship W3036476658A5066939276 @default.
- W3036476658 hasAuthorship W3036476658A5079955860 @default.
- W3036476658 hasAuthorship W3036476658A5085320315 @default.
- W3036476658 hasAuthorship W3036476658A5088959418 @default.
- W3036476658 hasAuthorship W3036476658A5089347460 @default.
- W3036476658 hasAuthorship W3036476658A5091621724 @default.
- W3036476658 hasBestOaLocation W30364766581 @default.
- W3036476658 hasConcept C104317684 @default.
- W3036476658 hasConcept C159110408 @default.
- W3036476658 hasConcept C178790620 @default.