Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036502456> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3036502456 abstract "Bone morphogenetic protein-4 (Bmp-4) is a member of the Transforming Growth Factor-β (TGF-β) superfamily of secreted signalling molecules. In this work, I have investigated its spatiotemporal distribution and possible function in the developing chick eye. The chick homologue of Bmp-4 is expressed throughout the developing chicken optic vesicle between Hamburger and Hamilton stages 13 and 17. It then shows a distinctive restriction to the dorsal quadrant of the eye until stage 30, when expression begins to fade, becoming undetectable by stage 35. Transcripts of the homeobox-containing gene GH6 show a similar dorsal restriction to Bmp-4, but between stages 20-35. Overexpression of Bmp-4 in vivo results in no detectable change in eye morphology, but enlarges the expression domain of GH6, indicating that the two genes may form part of a gene cascade involved in patterning the eye. In vitro, BMP-4 appears to stimulate retinal cell proliferation. It has no effect on retinal cell differentiation in vitro. In the chick, the patterning activities of sonic hedgehog (shh) are known to involve activation of Bmp expression in at least two instances; the development of the limb and midgut. I report here that shh is not expressed in the chick eye at all during development, but is found in the ventral portion of the diencephalon (forebrain). The available data suggests a number of roles for BMP-4 in chick eye development. BMP-4 may specify dorso-ventral retinal polarity required for proper retinal axon pathfinding, or establish a dorso-ventral gradient of cell proliferation in the developing optic cup. Alternatively, it may act as a hedgehog family member antagonist in establishing the retinal identity of the most dorsal portion of the eyecup." @default.
- W3036502456 created "2020-06-25" @default.
- W3036502456 creator A5060826339 @default.
- W3036502456 date "1996-01-01" @default.
- W3036502456 modified "2023-09-24" @default.
- W3036502456 title "The role of bone morphogenetic protein-4 in the developing chick eye" @default.
- W3036502456 hasPublicationYear "1996" @default.
- W3036502456 type Work @default.
- W3036502456 sameAs 3036502456 @default.
- W3036502456 citedByCount "0" @default.
- W3036502456 crossrefType "dissertation" @default.
- W3036502456 hasAuthorship W3036502456A5060826339 @default.
- W3036502456 hasConcept C104317684 @default.
- W3036502456 hasConcept C105702510 @default.
- W3036502456 hasConcept C114696181 @default.
- W3036502456 hasConcept C121587040 @default.
- W3036502456 hasConcept C196843134 @default.
- W3036502456 hasConcept C25770073 @default.
- W3036502456 hasConcept C2776637008 @default.
- W3036502456 hasConcept C2777329699 @default.
- W3036502456 hasConcept C2778761762 @default.
- W3036502456 hasConcept C2779530196 @default.
- W3036502456 hasConcept C2780827179 @default.
- W3036502456 hasConcept C2781316418 @default.
- W3036502456 hasConcept C31507581 @default.
- W3036502456 hasConcept C51816534 @default.
- W3036502456 hasConcept C54355233 @default.
- W3036502456 hasConcept C55493867 @default.
- W3036502456 hasConcept C62478195 @default.
- W3036502456 hasConcept C69125201 @default.
- W3036502456 hasConcept C86339819 @default.
- W3036502456 hasConcept C86803240 @default.
- W3036502456 hasConcept C95444343 @default.
- W3036502456 hasConceptScore W3036502456C104317684 @default.
- W3036502456 hasConceptScore W3036502456C105702510 @default.
- W3036502456 hasConceptScore W3036502456C114696181 @default.
- W3036502456 hasConceptScore W3036502456C121587040 @default.
- W3036502456 hasConceptScore W3036502456C196843134 @default.
- W3036502456 hasConceptScore W3036502456C25770073 @default.
- W3036502456 hasConceptScore W3036502456C2776637008 @default.
- W3036502456 hasConceptScore W3036502456C2777329699 @default.
- W3036502456 hasConceptScore W3036502456C2778761762 @default.
- W3036502456 hasConceptScore W3036502456C2779530196 @default.
- W3036502456 hasConceptScore W3036502456C2780827179 @default.
- W3036502456 hasConceptScore W3036502456C2781316418 @default.
- W3036502456 hasConceptScore W3036502456C31507581 @default.
- W3036502456 hasConceptScore W3036502456C51816534 @default.
- W3036502456 hasConceptScore W3036502456C54355233 @default.
- W3036502456 hasConceptScore W3036502456C55493867 @default.
- W3036502456 hasConceptScore W3036502456C62478195 @default.
- W3036502456 hasConceptScore W3036502456C69125201 @default.
- W3036502456 hasConceptScore W3036502456C86339819 @default.
- W3036502456 hasConceptScore W3036502456C86803240 @default.
- W3036502456 hasConceptScore W3036502456C95444343 @default.
- W3036502456 hasLocation W30365024561 @default.
- W3036502456 hasOpenAccess W3036502456 @default.
- W3036502456 hasPrimaryLocation W30365024561 @default.
- W3036502456 hasRelatedWork W1779045446 @default.
- W3036502456 hasRelatedWork W1794666008 @default.
- W3036502456 hasRelatedWork W1804794972 @default.
- W3036502456 hasRelatedWork W1844859101 @default.
- W3036502456 hasRelatedWork W1888262718 @default.
- W3036502456 hasRelatedWork W1995418302 @default.
- W3036502456 hasRelatedWork W2002385895 @default.
- W3036502456 hasRelatedWork W2005700941 @default.
- W3036502456 hasRelatedWork W2037408712 @default.
- W3036502456 hasRelatedWork W2040003312 @default.
- W3036502456 hasRelatedWork W2065269201 @default.
- W3036502456 hasRelatedWork W2068169334 @default.
- W3036502456 hasRelatedWork W2131983181 @default.
- W3036502456 hasRelatedWork W2154883208 @default.
- W3036502456 hasRelatedWork W2154920883 @default.
- W3036502456 hasRelatedWork W2163542654 @default.
- W3036502456 hasRelatedWork W2181972336 @default.
- W3036502456 hasRelatedWork W2741995798 @default.
- W3036502456 hasRelatedWork W2924999518 @default.
- W3036502456 hasRelatedWork W3022829202 @default.
- W3036502456 isParatext "false" @default.
- W3036502456 isRetracted "false" @default.
- W3036502456 magId "3036502456" @default.
- W3036502456 workType "dissertation" @default.