FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036502714> ?p ?o ?g. }

• W3036502714 endingPage "2403" @default.
• W3036502714 startingPage "2384" @default.
• W3036502714 abstract "The “vicious cycle” established between tumor growth and osteolysis aggravates the process of breast cancer bone metastasis, leading to life-threatening skeletal-related events that severely reduce survival and quality of life. To effectively interrupt the “vicious cycle”, innovative therapeutic strategies that not only reduce osteolysis but also relieve tumor burden are urgently needed. Herein, a bone-seeking moiety, alendronate (ALN), functionalized coordination polymer nanoparticles ([email protected]) co-delivering cisplatin prodrug (DSP) and antiresorptive agent zoledronate (ZOL) via Zn2+ crosslinking for combination therapy was reported. The versatile [email protected] with a diameter of about 40 nm can cross the fissure in the bone marrow sinus capillaries, and possesses an excellent bone-seeking ability both in vitro and in vivo. Additionally, [email protected] could synergistically inhibit the proliferation of cancer cells, suppress the formation of osteoclast-like cells and induce the apoptosis of osteoclasts in vitro. Importantly, it could preferentially accumulate in bone affected site, remarkably inhibit the proliferation of tumor cells, relieving bone pain, and significantly inhibit the activation of osteoclasts, protecting the bone from destruction in vivo, eventually leading to the breakdown of “vicious cycle” without inducing obvious systemic toxicity. This innovative nanoagent combines chemotherapy and osteolysis inhibition, exhibiting an inspiring strategy for effective treatment of bone metastasis." @default.
• W3036502714 created "2020-06-25" @default.
• W3036502714 creator A5009110420 @default.
• W3036502714 creator A5024244640 @default.
• W3036502714 creator A5027345042 @default.
• W3036502714 creator A5056672927 @default.
• W3036502714 creator A5064030061 @default.
• W3036502714 creator A5072289684 @default.
• W3036502714 creator A5088834307 @default.
• W3036502714 date "2020-12-01" @default.
• W3036502714 modified "2023-10-15" @default.
• W3036502714 title "Bone-seeking nanoplatform co-delivering cisplatin and zoledronate for synergistic therapy of breast cancer bone metastasis and bone resorption" @default.
• W3036502714 cites W1585966599 @default.
• W3036502714 cites W1603024307 @default.
• W3036502714 cites W1834592195 @default.
• W3036502714 cites W1938796902 @default.
• W3036502714 cites W1964041814 @default.
• W3036502714 cites W1967479801 @default.
• W3036502714 cites W1968377063 @default.
• W3036502714 cites W1968647565 @default.
• W3036502714 cites W1970247466 @default.
• W3036502714 cites W1974693247 @default.
• W3036502714 cites W1980961223 @default.
• W3036502714 cites W1990621588 @default.
• W3036502714 cites W2003213153 @default.
• W3036502714 cites W2009672068 @default.
• W3036502714 cites W2012108057 @default.
• W3036502714 cites W2033887870 @default.
• W3036502714 cites W2040435660 @default.
• W3036502714 cites W2046935809 @default.
• W3036502714 cites W2057995538 @default.
• W3036502714 cites W2077546229 @default.
• W3036502714 cites W2087324367 @default.
• W3036502714 cites W2087408588 @default.
• W3036502714 cites W2089220360 @default.
• W3036502714 cites W2093309943 @default.
• W3036502714 cites W2097743908 @default.
• W3036502714 cites W2121917721 @default.
• W3036502714 cites W2130177169 @default.
• W3036502714 cites W2133514604 @default.
• W3036502714 cites W2134539328 @default.
• W3036502714 cites W2136646477 @default.
• W3036502714 cites W2137935883 @default.
• W3036502714 cites W2142234592 @default.
• W3036502714 cites W2153046528 @default.
• W3036502714 cites W2157068238 @default.
• W3036502714 cites W2200671523 @default.
• W3036502714 cites W2263103339 @default.
• W3036502714 cites W2282989227 @default.
• W3036502714 cites W2335598274 @default.
• W3036502714 cites W2440836370 @default.
• W3036502714 cites W2555913913 @default.
• W3036502714 cites W2580488838 @default.
• W3036502714 cites W2622388056 @default.
• W3036502714 cites W2733284979 @default.
• W3036502714 cites W2750422302 @default.
• W3036502714 cites W2754408721 @default.
• W3036502714 cites W2768549821 @default.
• W3036502714 cites W2768831481 @default.
• W3036502714 cites W2782330970 @default.
• W3036502714 cites W2808895931 @default.
• W3036502714 cites W2886801809 @default.
• W3036502714 cites W2892234095 @default.
• W3036502714 cites W2896164687 @default.
• W3036502714 cites W2917542703 @default.
• W3036502714 cites W2928628825 @default.
• W3036502714 cites W2953503600 @default.
• W3036502714 cites W2965711249 @default.
• W3036502714 cites W2988326134 @default.
• W3036502714 cites W2997802496 @default.
• W3036502714 doi "https://doi.org/10.1016/j.apsb.2020.06.006" @default.
• W3036502714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7745129" @default.
• W3036502714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33354509" @default.
• W3036502714 hasPublicationYear "2020" @default.
• W3036502714 type Work @default.
• W3036502714 sameAs 3036502714 @default.
• W3036502714 citedByCount "18" @default.
• W3036502714 countsByYear W30365027142021 @default.
• W3036502714 countsByYear W30365027142022 @default.
• W3036502714 countsByYear W30365027142023 @default.
• W3036502714 crossrefType "journal-article" @default.
• W3036502714 hasAuthorship W3036502714A5009110420 @default.
• W3036502714 hasAuthorship W3036502714A5024244640 @default.
• W3036502714 hasAuthorship W3036502714A5027345042 @default.
• W3036502714 hasAuthorship W3036502714A5056672927 @default.
• W3036502714 hasAuthorship W3036502714A5064030061 @default.
• W3036502714 hasAuthorship W3036502714A5072289684 @default.
• W3036502714 hasAuthorship W3036502714A5088834307 @default.
• W3036502714 hasBestOaLocation W30365027141 @default.
• W3036502714 hasConcept C121608353 @default.
• W3036502714 hasConcept C126322002 @default.
• W3036502714 hasConcept C141071460 @default.
• W3036502714 hasConcept C150903083 @default.
• W3036502714 hasConcept C170493617 @default.
• W3036502714 hasConcept C185592680 @default.
• W3036502714 hasConcept C207001950 @default.
• W3036502714 hasConcept C2776033226 @default.
• W3036502714 hasConcept C2776541429 @default.

• next