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• W3036509711 abstract "Purpose The purpose of this study was to investigate the relationship between the lamina cribrosa (LC) thickness (LCT) as assessed using enhanced depth-imaging (EDI) optical coherence tomography (OCT) and cognitive function in primary open-angle glaucoma (POAG). Methods The study consisted of 105 POAG eyes and 23 nonglaucomatous control eyes that completed neuropsychological tests. The optic nerve heads of the patients were imaged using EDI-OCT. B-scan images were constructed in three dimensions using maximum intensity projection (MIP), and the LCT was measured using the thin-slab MIP images. A comprehensive battery consisting of 15 neuropsychological tests was used to evaluate cognitive function. Results POAG eyes had smaller mean LCT as compared with control eyes (P < 0.001). Age and Mini Mental State Examination (MMSE) scores did not differ between the two groups. Linear regression analysis revealed that lower scores on the MMSE (P < 0.001), presence of glaucoma (P = 0.006), and a smaller global retinal nerve fiber layer thickness (P < 0.001) were independently associated with a smaller mean LCT. Davies' test revealed a statistically significant breakpoint for the mean LCT (221.14 µm), below which a smaller MMSE score was significantly associated with a smaller mean LCT. In POAG eyes with a mean LCT smaller than the breakpoint (< 221.14 µm), not only the global cognition but also the visuospatial function and visual memory were worse than in those with a larger mean LCT (all P ≤ 0.003). Conclusions Impairment of cognitive function was observed in patients with POAG with a thinner LC. The role of LC imaging as a potential biomarker to monitor cognitive impairment needs further investigation. Translational Relevance LC thinning may reflect a shared mechanism of neurodegenerative diseases in the brain and optic nerve." @default.
• W3036509711 created "2020-06-25" @default.
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• W3036509711 date "2020-06-17" @default.
• W3036509711 modified "2023-10-16" @default.
• W3036509711 title "Cognitive Impairment and Lamina Cribrosa Thickness in Primary Open-Angle Glaucoma" @default.
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• W3036509711 doi "https://doi.org/10.1167/tvst.9.7.17" @default.
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