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- W3036565587 abstract "Summary In the adult ventricular-subventricular zone (V-SVZ), neural stem cells (NSCs) generate new olfactory bulb (OB) neurons and glia throughout life. To map adult neuronal lineage progression, we profiled >56,000 V-SVZ and OB cells by single-cell RNA sequencing (scRNA-seq). Our analyses reveal the molecular diversity of OB neurons, including fate-mapped neurons, lineage progression dynamics, and an NSC intermediate enriched for Notum, which encodes a secreted WNT antagonist. SCOPE-seq technology, which links live-cell imaging with scRNA-seq, uncovers cell-size transitions during NSC differentiation and preferential NOTUM binding to proliferating neuronal precursors. Consistently, application of NOTUM protein in slice cultures and pharmacological inhibition of NOTUM in slice cultures and in vivo demonstrated that NOTUM negatively regulates V-SVZ proliferation. Timely, context-dependent neurogenesis demands adaptive signaling among neighboring progenitors. Our findings highlight a critical regulatory state during NSC activation marked by NOTUM, which attenuates WNT-stimulated proliferation in NSC progeny." @default.
- W3036565587 created "2020-06-25" @default.
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- W3036565587 date "2020-06-01" @default.
- W3036565587 modified "2023-10-18" @default.
- W3036565587 title "Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator" @default.
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- W3036565587 cites W1949398079 @default.
- W3036565587 cites W1967327758 @default.
- W3036565587 cites W1967611229 @default.
- W3036565587 cites W1968880709 @default.
- W3036565587 cites W1983623527 @default.
- W3036565587 cites W1988352722 @default.
- W3036565587 cites W1990044878 @default.
- W3036565587 cites W2014407542 @default.
- W3036565587 cites W2026598324 @default.
- W3036565587 cites W2030722162 @default.
- W3036565587 cites W2031228451 @default.
- W3036565587 cites W2031407988 @default.
- W3036565587 cites W2035914283 @default.
- W3036565587 cites W2044110964 @default.
- W3036565587 cites W2048086625 @default.
- W3036565587 cites W2053145106 @default.
- W3036565587 cites W2054275187 @default.
- W3036565587 cites W2055055895 @default.
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- W3036565587 cites W2088973714 @default.
- W3036565587 cites W2092730586 @default.
- W3036565587 cites W2094065018 @default.
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- W3036565587 cites W2109178214 @default.
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- W3036565587 cites W2130410032 @default.
- W3036565587 cites W2132093497 @default.
- W3036565587 cites W2135937351 @default.
- W3036565587 cites W2139388215 @default.
- W3036565587 cites W2142435792 @default.
- W3036565587 cites W2144511710 @default.
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- W3036565587 cites W2149554987 @default.
- W3036565587 cites W2154307309 @default.
- W3036565587 cites W2165867905 @default.
- W3036565587 cites W2167279371 @default.
- W3036565587 cites W2169456326 @default.
- W3036565587 cites W2172266256 @default.
- W3036565587 cites W2183886647 @default.
- W3036565587 cites W2292471654 @default.
- W3036565587 cites W2409842303 @default.
- W3036565587 cites W2510746232 @default.
- W3036565587 cites W2522918785 @default.
- W3036565587 cites W2524461462 @default.
- W3036565587 cites W2593787193 @default.
- W3036565587 cites W2600281252 @default.
- W3036565587 cites W2611513048 @default.
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- W3036565587 cites W2786235809 @default.
- W3036565587 cites W2803307082 @default.
- W3036565587 cites W2810097927 @default.
- W3036565587 cites W2813292791 @default.
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- W3036565587 cites W2903487479 @default.
- W3036565587 cites W2906427371 @default.
- W3036565587 cites W2909032196 @default.
- W3036565587 cites W2915097886 @default.
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- W3036565587 doi "https://doi.org/10.1016/j.celrep.2020.107805" @default.
- W3036565587 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7396151" @default.
- W3036565587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32579931" @default.
- W3036565587 hasPublicationYear "2020" @default.
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