Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036573642> ?p ?o ?g. }
- W3036573642 endingPage "475" @default.
- W3036573642 startingPage "463" @default.
- W3036573642 abstract "The review is devoted to the relations between human microbiome and physiologic and pathologic processes an aging organism. Last years, there were obtained many convincing evidences of the huge microbiome influence on different processes of the human organism functioning, including behavior and brain biochemistry. Basing on these data, specialists consider the microbiome as an additional human organ that actively participates in digestion, management of metabolic processes, maintenance of epithelial barrier integrity, development and strengthening the immune system and a number of other physiologic functions. Therefore, it optimizes conditions for the normal vital activity of the human organism on the whole. Many scientists consider aging as a chronic inflammatory process that is accompanied by unfavorable changes of the microbiome structure and functional activity. In most cases, age-related microbiome changes have negative influence on the health state, since they result in disorders of functional activity of microbe communities and failures of the metabolic chains that play the important role in functioning of many organs. It is well known that in elderly age, multiform interactions between the human organism and associated microbe communities undergo complicated changes, which may lead to strong phenotypic consequences, including dysbiosis, infections, psychosomatic diseases and general worsening of the organism functional state. It is assumed that an in-depth study of these processes with the development of age-related pathologies may facilitate the solution of many geriatrics problems. In the review, modern information is generalized that concerns composition and functional activity of the microbiota in aged people as well as the impact of the changed microbiome on disease development. There were analyzed research aimed at using some means of microbiome improvement at different age-related pathology. In the judgment of specialists, prevention of microbiome disturbances, beginning from young age, is one of most important protective measures for improving quality of life of the older population. In particular, there have been carried out many researches and their results confirm the reasonability of using probiotics for improving the state of health in elderly age. Probiotics were shown to beneficially influence the microbiome, general physical and mental state and immune status in elderly people. It is believed that regular using of probiotics favours maintaining homeostatic state of gut mucous membrane and microbiota, which is a critical component of mode of life aimed at longevity. Besides probiotics, perspective means for improving microbiome of elderly people are prebiotics, products of functional nutrition and enterosorbents. “Rejuvenation” of microbiome by virtue of wide using modern health-improving means might be one of means for prevention diseases, premature aging and an immense improvement of quality of life in advanced age. Key words: microbiome, aging, metabolites, inflammation, dysbiosis, immunity, probiotics, prebiotics, synbiotics, enterosorbents. For citation: Shyrobokov VP, Yankovskyi DS, Dyment HS. Microbiome and human aging (literature review). Journal of the National Academy of Medical Sciences of Ukraine. 2019;25(4):463-75." @default.
- W3036573642 created "2020-06-25" @default.
- W3036573642 creator A5022607451 @default.
- W3036573642 creator A5034858791 @default.
- W3036573642 creator A5066697702 @default.
- W3036573642 date "2019-12-18" @default.
- W3036573642 modified "2023-09-30" @default.
- W3036573642 title "Microbiome and human aging (literature review)" @default.
- W3036573642 cites W1549775244 @default.
- W3036573642 cites W1550909633 @default.
- W3036573642 cites W1682365470 @default.
- W3036573642 cites W1828900086 @default.
- W3036573642 cites W1876232886 @default.
- W3036573642 cites W1968726185 @default.
- W3036573642 cites W1969635665 @default.
- W3036573642 cites W1971107109 @default.
- W3036573642 cites W1977804070 @default.
- W3036573642 cites W1980976488 @default.
- W3036573642 cites W1993001474 @default.
- W3036573642 cites W1993830991 @default.
- W3036573642 cites W1997312721 @default.
- W3036573642 cites W1999492971 @default.
- W3036573642 cites W2001343557 @default.
- W3036573642 cites W2002843109 @default.
- W3036573642 cites W2007006020 @default.
- W3036573642 cites W2014099400 @default.
- W3036573642 cites W2018672567 @default.
- W3036573642 cites W2025399737 @default.
- W3036573642 cites W2037420833 @default.
- W3036573642 cites W2040108545 @default.
- W3036573642 cites W2041751047 @default.
- W3036573642 cites W2043131385 @default.
- W3036573642 cites W2048479014 @default.
- W3036573642 cites W2052069040 @default.
- W3036573642 cites W2052091083 @default.
- W3036573642 cites W2054172123 @default.
- W3036573642 cites W2056593583 @default.
- W3036573642 cites W2057844433 @default.
- W3036573642 cites W2065891442 @default.
- W3036573642 cites W2073900522 @default.
- W3036573642 cites W2078146936 @default.
- W3036573642 cites W2079628735 @default.
- W3036573642 cites W2082441137 @default.
- W3036573642 cites W2082808164 @default.
- W3036573642 cites W2083900273 @default.
- W3036573642 cites W2087243986 @default.
- W3036573642 cites W2088170171 @default.
- W3036573642 cites W2096989541 @default.
- W3036573642 cites W2097937398 @default.
- W3036573642 cites W2100680564 @default.
- W3036573642 cites W2103728834 @default.
- W3036573642 cites W2105503795 @default.
- W3036573642 cites W2106503480 @default.
- W3036573642 cites W2111686162 @default.
- W3036573642 cites W2113876228 @default.
- W3036573642 cites W2118530133 @default.
- W3036573642 cites W2127013413 @default.
- W3036573642 cites W2131987394 @default.
- W3036573642 cites W2132209276 @default.
- W3036573642 cites W2132629114 @default.
- W3036573642 cites W2138497901 @default.
- W3036573642 cites W2140660542 @default.
- W3036573642 cites W2148067809 @default.
- W3036573642 cites W2149376991 @default.
- W3036573642 cites W2149515881 @default.
- W3036573642 cites W2155897723 @default.
- W3036573642 cites W2156573030 @default.
- W3036573642 cites W2161251845 @default.
- W3036573642 cites W2162088497 @default.
- W3036573642 cites W2162093804 @default.
- W3036573642 cites W2163182875 @default.
- W3036573642 cites W2164188362 @default.
- W3036573642 cites W2164420317 @default.
- W3036573642 cites W2170142813 @default.
- W3036573642 cites W2371807656 @default.
- W3036573642 cites W2401857311 @default.
- W3036573642 cites W2479642761 @default.
- W3036573642 cites W2583122059 @default.
- W3036573642 cites W2622475329 @default.
- W3036573642 cites W2767624273 @default.
- W3036573642 cites W2769629043 @default.
- W3036573642 cites W2786077795 @default.
- W3036573642 cites W2802500969 @default.
- W3036573642 cites W2883007653 @default.
- W3036573642 cites W2884526266 @default.
- W3036573642 cites W2907249267 @default.
- W3036573642 cites W366207423 @default.
- W3036573642 doi "https://doi.org/10.37621/jnamsu-2019-4-463-475" @default.
- W3036573642 hasPublicationYear "2019" @default.
- W3036573642 type Work @default.
- W3036573642 sameAs 3036573642 @default.
- W3036573642 citedByCount "1" @default.
- W3036573642 countsByYear W30365736422021 @default.
- W3036573642 crossrefType "journal-article" @default.
- W3036573642 hasAuthorship W3036573642A5022607451 @default.
- W3036573642 hasAuthorship W3036573642A5034858791 @default.
- W3036573642 hasAuthorship W3036573642A5066697702 @default.
- W3036573642 hasBestOaLocation W30365736421 @default.