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- W3036575476 abstract "The distribution of ion channels and receptors over the neuronal surface is important for the receipt of incoming synaptic inputs and for the integration of these inputs. Most voltage-gated and ligand-gated ion channels have non-homogeneous distributions in the neuronal membrane, many being restricted to either dendritic, axonal or somatic domains and further localized within these domains to regions such as dendritic spines, nodes of Ranvier or synaptic junctions (1-3). For example voltage-dependent calcium channels are localized and immobilized on dendrites (4), while voltage-dependent sodium channel are localized on axon hillocks (5) and nodes of Ranvier. Determining where and how ion channels are distributed and maintained is important for a variety of reasons. Ion channels in growth cones have a role in neurite outgrowth mechanisms (6), they are obligatory for synaptic transmission and they are required for amplification of neurotransmitter signals in the post synaptic membrane (7). Changes in ion channel distributions are an important aspect in development and plasticity (8,9)." @default.
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- W3036575476 title "Distribution and modulation of ion channel and receptor topography on nerve cell surfaces" @default.
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- W3036575476 doi "https://doi.org/10.1017/s0424820100146011" @default.
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