Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036577075> ?p ?o ?g. }
- W3036577075 abstract "Abstract COVID-19, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), represents a global crisis. Key to SARS-CoV-2 therapeutic development is unraveling the mechanisms driving high infectivity, broad tissue tropism and severe pathology. Our cryo-EM structure of SARS-CoV-2 spike (S) glycoprotein reveals that the receptor binding domains (RBDs) tightly and specifically bind the essential free fatty acid (FFA) linoleic acid (LA) in three composite binding pockets. The pocket also appears to be present in the highly pathogenic coronaviruses SARS-CoV and MERS-CoV. Lipid metabolome remodeling is a key feature of coronavirus infection, with LA at its core. LA metabolic pathways are central to inflammation, immune modulation and membrane fluidity. Our structure directly links LA and S, setting the stage for interventions targeting LA binding and metabolic remodeling by SARS-CoV-2. One Sentence Summary A direct structural link between SARS-CoV-2 spike and linoleic acid, a key molecule in inflammation, immune modulation and membrane fluidity." @default.
- W3036577075 created "2020-06-25" @default.
- W3036577075 creator A5005998309 @default.
- W3036577075 creator A5011195205 @default.
- W3036577075 creator A5013136404 @default.
- W3036577075 creator A5013411572 @default.
- W3036577075 creator A5013799671 @default.
- W3036577075 creator A5027002310 @default.
- W3036577075 creator A5030664364 @default.
- W3036577075 creator A5044560485 @default.
- W3036577075 creator A5064578149 @default.
- W3036577075 creator A5077652674 @default.
- W3036577075 creator A5091178241 @default.
- W3036577075 date "2020-06-18" @default.
- W3036577075 modified "2023-09-22" @default.
- W3036577075 title "Unexpected free fatty acid binding pocket in the cryo-EM structure of SARS-CoV-2 spike protein" @default.
- W3036577075 cites W1838872057 @default.
- W3036577075 cites W1982533785 @default.
- W3036577075 cites W2005690045 @default.
- W3036577075 cites W2019079360 @default.
- W3036577075 cites W2020707234 @default.
- W3036577075 cites W2026920658 @default.
- W3036577075 cites W2032493002 @default.
- W3036577075 cites W2034200621 @default.
- W3036577075 cites W2038766861 @default.
- W3036577075 cites W2062575193 @default.
- W3036577075 cites W2064140868 @default.
- W3036577075 cites W2098167941 @default.
- W3036577075 cites W2104234755 @default.
- W3036577075 cites W2124026197 @default.
- W3036577075 cites W2154714625 @default.
- W3036577075 cites W2176430082 @default.
- W3036577075 cites W2255243349 @default.
- W3036577075 cites W2520033800 @default.
- W3036577075 cites W2593511418 @default.
- W3036577075 cites W2606148195 @default.
- W3036577075 cites W2620083990 @default.
- W3036577075 cites W2788833468 @default.
- W3036577075 cites W2910499089 @default.
- W3036577075 cites W2941432874 @default.
- W3036577075 cites W2948622157 @default.
- W3036577075 cites W2953320394 @default.
- W3036577075 cites W2971877727 @default.
- W3036577075 cites W2973457155 @default.
- W3036577075 cites W2974351312 @default.
- W3036577075 cites W2981663786 @default.
- W3036577075 cites W3004280078 @default.
- W3036577075 cites W3008178761 @default.
- W3036577075 cites W3008394341 @default.
- W3036577075 cites W3009859788 @default.
- W3036577075 cites W3009912996 @default.
- W3036577075 cites W3010955108 @default.
- W3036577075 cites W3011134208 @default.
- W3036577075 cites W3011489077 @default.
- W3036577075 cites W3014067025 @default.
- W3036577075 cites W3017125154 @default.
- W3036577075 cites W3017302293 @default.
- W3036577075 cites W3018517500 @default.
- W3036577075 cites W3028711203 @default.
- W3036577075 doi "https://doi.org/10.1101/2020.06.18.158584" @default.
- W3036577075 hasPublicationYear "2020" @default.
- W3036577075 type Work @default.
- W3036577075 sameAs 3036577075 @default.
- W3036577075 citedByCount "9" @default.
- W3036577075 countsByYear W30365770752020 @default.
- W3036577075 countsByYear W30365770752021 @default.
- W3036577075 countsByYear W30365770752022 @default.
- W3036577075 crossrefType "posted-content" @default.
- W3036577075 hasAuthorship W3036577075A5005998309 @default.
- W3036577075 hasAuthorship W3036577075A5011195205 @default.
- W3036577075 hasAuthorship W3036577075A5013136404 @default.
- W3036577075 hasAuthorship W3036577075A5013411572 @default.
- W3036577075 hasAuthorship W3036577075A5013799671 @default.
- W3036577075 hasAuthorship W3036577075A5027002310 @default.
- W3036577075 hasAuthorship W3036577075A5030664364 @default.
- W3036577075 hasAuthorship W3036577075A5044560485 @default.
- W3036577075 hasAuthorship W3036577075A5064578149 @default.
- W3036577075 hasAuthorship W3036577075A5077652674 @default.
- W3036577075 hasAuthorship W3036577075A5091178241 @default.
- W3036577075 hasBestOaLocation W30365770751 @default.
- W3036577075 hasConcept C142724271 @default.
- W3036577075 hasConcept C170493617 @default.
- W3036577075 hasConcept C185592680 @default.
- W3036577075 hasConcept C203014093 @default.
- W3036577075 hasConcept C2776914184 @default.
- W3036577075 hasConcept C2777648638 @default.
- W3036577075 hasConcept C2779134260 @default.
- W3036577075 hasConcept C3007834351 @default.
- W3036577075 hasConcept C3008058167 @default.
- W3036577075 hasConcept C51639874 @default.
- W3036577075 hasConcept C524204448 @default.
- W3036577075 hasConcept C55493867 @default.
- W3036577075 hasConcept C71924100 @default.
- W3036577075 hasConcept C86803240 @default.
- W3036577075 hasConcept C8891405 @default.
- W3036577075 hasConcept C95444343 @default.
- W3036577075 hasConceptScore W3036577075C142724271 @default.
- W3036577075 hasConceptScore W3036577075C170493617 @default.
- W3036577075 hasConceptScore W3036577075C185592680 @default.
- W3036577075 hasConceptScore W3036577075C203014093 @default.