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- W3036587054 abstract "Spinal cord trauma is a major health problem in terms of morbidity and mortality. It is clear that traumatic spinal cord injury is related to the death of a cord segment which results in the structural and functional disruption of key pathways vital to the maintenance of normal neurological function. The injured area of the cord eventually becomes a zone of segmental necrosis which, in the more severe cases, involves all but a thin rim of sub-pial white matter. The clinical consequences of segmental necrosis can be consistently reproduced in experimental animals by dropping weights onto the surgically exposed cord. At the moment of impact and during the primary injury phase, there are changes in the spinal cord which indicate that neural membranes are altered. The extent and reversibility of these alterations are being investigated for therapeutic treatment. Emphasis has been placed principally on secondary events leading to calcium toxicity. An ultra-rapid freezing technique evolved from the necessity of preserving diffusible ions in situ before and after spinal cord injury." @default.
- W3036587054 created "2020-06-25" @default.
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- W3036587054 date "1993-08-01" @default.
- W3036587054 modified "2023-09-25" @default.
- W3036587054 title "In situ cryofixation of rat spinal cord by a new propane jet freezing device" @default.
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- W3036587054 doi "https://doi.org/10.1017/s0424820100146357" @default.
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