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• W3036606543 abstract "Abstract Nuclear pore complexes (NPCs) are the main conduits for molecular exchange across the nuclear envelope. The NPC is a modular assembly of ~500 individual proteins, called nucleoporins or nups. Most scaffolding nups are organized in two multimeric subcomplexes, the Nup84 or Y complex and the Nic96 or inner ring complex. Working in S. cerevisiae , and to study the assembly of these two essential subcomplexes, we developed a set of twelve nanobodies that recognize seven constituent nucleoporins of the Y and Nic96 complexes. These nanobodies all bind specifically and with high affinity. We present structures of several nup-nanobody complexes, revealing their binding sites. Additionally, constitutive expression of the nanobody suite in S. cerevisiae revealed accessible and obstructed surfaces of the Y complex and Nic96 within the NPC. Overall, this suite of nanobodies provides a unique and versatile toolkit for the study of the NPC." @default.
• W3036606543 created "2020-06-25" @default.
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• W3036606543 date "2020-06-20" @default.
• W3036606543 modified "2023-09-27" @default.
• W3036606543 title "A nanobody suite for yeast scaffold nucleoporins provides details of the Nuclear Pore Complex structure" @default.
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• W3036606543 doi "https://doi.org/10.1101/2020.06.19.161075" @default.
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