Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036648905> ?p ?o ?g. }
- W3036648905 abstract "Abstract The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans, secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such as albumin and antithrombin associated with the endothelial surface. The glycocalyx plays an important role in vascular homeostasis, regulating vascular permeability and cell adhesion, and acts as a mechanosensor for hemodynamic shear stresses; it also has antithrombotic and anti-inflammatory functions. Plasma proteins such as albumin are physiologically bound within the glycocalyx, thus contributing to stability of the layer. Albumin is the major determinant of plasma colloid osmotic pressure. In addition, albumin transports sphingosine-1-phosphate which has protective endothelial effects, acts as a free radical scavenger, and has immunomodulatory and anti-inflammatory effects. This review examines the physiological function of the endothelial glycocalyx and the role of human albumin in preserving glycocalyx integrity and the microcirculation." @default.
- W3036648905 created "2020-06-25" @default.
- W3036648905 creator A5002903090 @default.
- W3036648905 creator A5006917212 @default.
- W3036648905 creator A5042382451 @default.
- W3036648905 creator A5066258641 @default.
- W3036648905 date "2020-06-22" @default.
- W3036648905 modified "2023-10-16" @default.
- W3036648905 title "Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review" @default.
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