FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036670708> ?p ?o ?g. }

• W3036670708 endingPage "1704" @default.
• W3036670708 startingPage "1699" @default.
• W3036670708 abstract "Abstract Background Klinefelter syndrome (KS) may induce skeletal fragility, but the studies so far published on this topic were mainly focused on the evaluation of bone mineral density (BMD) and bone microstructure, whereas data on fracture risk are still lacking. Objective To evaluate the prevalence and determinants of vertebral fractures (VFs), that is, the hallmark of osteoporosis, in subjects with KS. Materials and methods Eighty‐seven patients with KS (median age 41 years, range 18‐64) were consecutively evaluated for radiological VFs (by quantitative morphometry) and lumbar spine and femoral neck BMD (by DXA). Fifty‐five patients with KS were also evaluated by the fracture risk assessment (FRAX) tool. Results Low BMD was found in 22/87 (25.3%) patients [12 with osteopenia, three with osteoporosis and seven with “low BMD per age” (subject < 50 years with Z ‐score ≤−2.0 SD)] and VFs in 13/87 (14.9%) patients. In patients with VFs, the median spine deformity index was 2 (range 1‐9). Prevalence of VFs was similar between healthy and low‐BMD patients (15.9% vs 13.6%; P = .80). Noteworthy, patients with VFs had significantly higher age at diagnosis of KS as compared to patients who did not fracture ( P = .039), without significant differences in age at the time of observation ( P = .162), body mass index ( P = .234), testosterone replacement therapy ( P = .432), duration of testosterone therapy ( P = .409), vitamin D therapy ( P = 681), and serum testosterone levels ( P = .338). Moreover, patients with VFs were more likely to complain back pain in comparison with those without VFs (33.3% vs 7.4%; P = .047). In 55 cases evaluated by the FRAX® tool, no significant differences in 10‐year risk of major fracture ( P = .270) and hip fracture ( P = .860) were found between fractured and non‐fractured patients. Conclusions This study provides first evidence that KS may be associated with risk of VFs in close relationship with delay in disease diagnosis but independently of BMD values and serum testosterone levels or testosterone therapy." @default.
• W3036670708 created "2020-06-25" @default.
• W3036670708 creator A5006015349 @default.
• W3036670708 creator A5008599877 @default.
• W3036670708 creator A5011245991 @default.
• W3036670708 creator A5011653848 @default.
• W3036670708 creator A5018034717 @default.
• W3036670708 creator A5021896784 @default.
• W3036670708 creator A5039015290 @default.
• W3036670708 creator A5044615622 @default.
• W3036670708 creator A5044853731 @default.
• W3036670708 creator A5061194917 @default.
• W3036670708 creator A5064669371 @default.
• W3036670708 creator A5081941239 @default.
• W3036670708 creator A5086741973 @default.
• W3036670708 creator A5088579446 @default.
• W3036670708 date "2020-07-21" @default.
• W3036670708 modified "2023-10-11" @default.
• W3036670708 title "Prevalence and determinants of radiological vertebral fractures in patients with Klinefelter syndrome" @default.
• W3036670708 cites W1598136938 @default.
• W3036670708 cites W1967164400 @default.
• W3036670708 cites W1970674144 @default.
• W3036670708 cites W1974331805 @default.
• W3036670708 cites W1979553864 @default.
• W3036670708 cites W1979627788 @default.
• W3036670708 cites W1986533422 @default.
• W3036670708 cites W1988698688 @default.
• W3036670708 cites W1994324165 @default.
• W3036670708 cites W2003226042 @default.
• W3036670708 cites W2003593168 @default.
• W3036670708 cites W2009826691 @default.
• W3036670708 cites W2021682202 @default.
• W3036670708 cites W2030512814 @default.
• W3036670708 cites W2033401946 @default.
• W3036670708 cites W2047221936 @default.
• W3036670708 cites W2051696239 @default.
• W3036670708 cites W2058776400 @default.
• W3036670708 cites W2059650971 @default.
• W3036670708 cites W2065125823 @default.
• W3036670708 cites W2086674445 @default.
• W3036670708 cites W2110768118 @default.
• W3036670708 cites W2113473467 @default.
• W3036670708 cites W2122617439 @default.
• W3036670708 cites W2128214757 @default.
• W3036670708 cites W2148332863 @default.
• W3036670708 cites W2169114503 @default.
• W3036670708 cites W2346394985 @default.
• W3036670708 cites W2397074409 @default.
• W3036670708 cites W2443640479 @default.
• W3036670708 cites W2522229769 @default.
• W3036670708 cites W2786926491 @default.
• W3036670708 cites W2792905913 @default.
• W3036670708 cites W2793859005 @default.
• W3036670708 cites W2802757031 @default.
• W3036670708 cites W2900096764 @default.
• W3036670708 cites W2914896381 @default.
• W3036670708 cites W2922458773 @default.
• W3036670708 cites W591744677 @default.
• W3036670708 doi "https://doi.org/10.1111/andr.12841" @default.
• W3036670708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32558374" @default.
• W3036670708 hasPublicationYear "2020" @default.
• W3036670708 type Work @default.
• W3036670708 sameAs 3036670708 @default.
• W3036670708 citedByCount "17" @default.
• W3036670708 countsByYear W30366707082020 @default.
• W3036670708 countsByYear W30366707082021 @default.
• W3036670708 countsByYear W30366707082022 @default.
• W3036670708 countsByYear W30366707082023 @default.
• W3036670708 crossrefType "journal-article" @default.
• W3036670708 hasAuthorship W3036670708A5006015349 @default.
• W3036670708 hasAuthorship W3036670708A5008599877 @default.
• W3036670708 hasAuthorship W3036670708A5011245991 @default.
• W3036670708 hasAuthorship W3036670708A5011653848 @default.
• W3036670708 hasAuthorship W3036670708A5018034717 @default.
• W3036670708 hasAuthorship W3036670708A5021896784 @default.
• W3036670708 hasAuthorship W3036670708A5039015290 @default.
• W3036670708 hasAuthorship W3036670708A5044615622 @default.
• W3036670708 hasAuthorship W3036670708A5044853731 @default.
• W3036670708 hasAuthorship W3036670708A5061194917 @default.
• W3036670708 hasAuthorship W3036670708A5064669371 @default.
• W3036670708 hasAuthorship W3036670708A5081941239 @default.
• W3036670708 hasAuthorship W3036670708A5086741973 @default.
• W3036670708 hasAuthorship W3036670708A5088579446 @default.
• W3036670708 hasBestOaLocation W30366707081 @default.
• W3036670708 hasConcept C126322002 @default.
• W3036670708 hasConcept C126894567 @default.
• W3036670708 hasConcept C141071460 @default.
• W3036670708 hasConcept C2775854910 @default.
• W3036670708 hasConcept C2776541429 @default.
• W3036670708 hasConcept C2776886416 @default.
• W3036670708 hasConcept C2777083390 @default.
• W3036670708 hasConcept C2777525943 @default.
• W3036670708 hasConcept C2779329777 @default.
• W3036670708 hasConcept C2779982284 @default.
• W3036670708 hasConcept C2780221984 @default.
• W3036670708 hasConcept C2994343686 @default.
• W3036670708 hasConcept C71924100 @default.
• W3036670708 hasConceptScore W3036670708C126322002 @default.

• next