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- W3036675135 abstract "Nitrofuran derivatives have been known to have a strong inhibitory effect on azo dye hepatic carcinogenesis when they are fed to rats simultaneously with an azo dye (Miyaki et al., 1969; Miyaji, 1971; Akao et al., 1971). It is assumed that the nitrofurans retarded the induction of hepatomas because they stimulate RNA-polymerase activity of liver nuclei inhibited by azo dye feeding (Akao et al., 1972; 1974) Male rats were fed a rice diet containing 0, 06% 4-dimethylamino- azobenzene (DAB) and 0, 2% furaciline /semicarbason-5-nitrofurfurole/ (F 6 ) for 6 months. Their liver tissue was then examined by light and electron microscopy at different intervals for 14 months. Strong inhibitory effect of F 6 on DAB-carcinogenesis was found. The changes produced in hepatocytes by F 6 included the hypertrophy of nucleolus, disorganization and slight reduction of granular endoplasmic reticulum (GER), moderate hyperplasia of agranular endoplasmic reticulum (AER), swelling of some mitochondria and diminition of glycogen content /Figs. 1-2/." @default.
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- W3036675135 date "1978-08-01" @default.
- W3036675135 modified "2023-09-26" @default.
- W3036675135 title "Ultrastructural changes in the rat hepatocytes during azo dye carcinogenesis modified by furaciline" @default.
- W3036675135 doi "https://doi.org/10.1017/s0424820100083473" @default.
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