Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036682786> ?p ?o ?g. }
- W3036682786 endingPage "110441" @default.
- W3036682786 startingPage "110441" @default.
- W3036682786 abstract "Caffeine (1,3,7-trimethylxanthine) is a xanthine alkaloid found in a number of dietary products consumed worldwide, such as coffee, tea, and soft beverages, and is known to act as a modifying agent for cytotoxic chemotherapeutic drugs. Studies have shown that caffeine reduces the cytotoxic effects of paclitaxel and inhibits paclitaxel-induced apoptosis; however, the underlying mechanism remains unclear. Here, we investigated whether caffeine inhibits the antitumor activity of paclitaxel via down-regulation of α-tubulin acetylation. In vitro studies, involving MTT assay, wound-healing assay, cell apoptosis assay, and western blotting analysis of A549 and HeLa cells, were performed. A549 and HeLa cell-based xenografts were established, and western blotting and immunohistochemical staining were performed for in vivo studies. The results showed that caffeine promoted the growth of cancer cells treated with paclitaxel. Additionally, caffeine enhanced migration ability, inhibited apoptosis, and decreased the acetylation of α-tubulin in paclitaxel-treated cancer cells. Furthermore, caffeine decreased the inhibitory effect of paclitaxel on tumor growth through down-regulation of α-tubulin acetylation in vivo. Taken together, these findings demonstrate that caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation, suggesting that patients receiving treatment with taxanes, such as paclitaxel, should avoid consuming caffeinated beverages or foods." @default.
- W3036682786 created "2020-06-25" @default.
- W3036682786 creator A5001424435 @default.
- W3036682786 creator A5014310469 @default.
- W3036682786 creator A5015236633 @default.
- W3036682786 creator A5046817249 @default.
- W3036682786 creator A5054147304 @default.
- W3036682786 creator A5056101783 @default.
- W3036682786 creator A5066448103 @default.
- W3036682786 creator A5087651798 @default.
- W3036682786 creator A5089130857 @default.
- W3036682786 date "2020-09-01" @default.
- W3036682786 modified "2023-10-16" @default.
- W3036682786 title "Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of α-tubulin acetylation" @default.
- W3036682786 cites W1023820744 @default.
- W3036682786 cites W1234904467 @default.
- W3036682786 cites W1586799290 @default.
- W3036682786 cites W1978003151 @default.
- W3036682786 cites W1983408354 @default.
- W3036682786 cites W1984374641 @default.
- W3036682786 cites W1997821158 @default.
- W3036682786 cites W2012883311 @default.
- W3036682786 cites W2057355058 @default.
- W3036682786 cites W2073194956 @default.
- W3036682786 cites W2086029092 @default.
- W3036682786 cites W2154747925 @default.
- W3036682786 cites W2170220266 @default.
- W3036682786 cites W2284891209 @default.
- W3036682786 cites W2554257031 @default.
- W3036682786 cites W2589109128 @default.
- W3036682786 cites W2795626400 @default.
- W3036682786 cites W2900409110 @default.
- W3036682786 cites W2903292083 @default.
- W3036682786 cites W2904043661 @default.
- W3036682786 cites W2909456234 @default.
- W3036682786 cites W2914860566 @default.
- W3036682786 cites W2925411057 @default.
- W3036682786 cites W2941675001 @default.
- W3036682786 cites W2982197835 @default.
- W3036682786 cites W2999417355 @default.
- W3036682786 cites W3000411337 @default.
- W3036682786 cites W4247615063 @default.
- W3036682786 cites W4255762755 @default.
- W3036682786 doi "https://doi.org/10.1016/j.biopha.2020.110441" @default.
- W3036682786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32580047" @default.
- W3036682786 hasPublicationYear "2020" @default.
- W3036682786 type Work @default.
- W3036682786 sameAs 3036682786 @default.
- W3036682786 citedByCount "7" @default.
- W3036682786 countsByYear W30366827862021 @default.
- W3036682786 countsByYear W30366827862022 @default.
- W3036682786 crossrefType "journal-article" @default.
- W3036682786 hasAuthorship W3036682786A5001424435 @default.
- W3036682786 hasAuthorship W3036682786A5014310469 @default.
- W3036682786 hasAuthorship W3036682786A5015236633 @default.
- W3036682786 hasAuthorship W3036682786A5046817249 @default.
- W3036682786 hasAuthorship W3036682786A5054147304 @default.
- W3036682786 hasAuthorship W3036682786A5056101783 @default.
- W3036682786 hasAuthorship W3036682786A5066448103 @default.
- W3036682786 hasAuthorship W3036682786A5087651798 @default.
- W3036682786 hasAuthorship W3036682786A5089130857 @default.
- W3036682786 hasBestOaLocation W30366827861 @default.
- W3036682786 hasConcept C104317684 @default.
- W3036682786 hasConcept C119157956 @default.
- W3036682786 hasConcept C121608353 @default.
- W3036682786 hasConcept C126322002 @default.
- W3036682786 hasConcept C134018914 @default.
- W3036682786 hasConcept C150903083 @default.
- W3036682786 hasConcept C185592680 @default.
- W3036682786 hasConcept C190283241 @default.
- W3036682786 hasConcept C202751555 @default.
- W3036682786 hasConcept C20418707 @default.
- W3036682786 hasConcept C207001950 @default.
- W3036682786 hasConcept C2777292972 @default.
- W3036682786 hasConcept C2777366897 @default.
- W3036682786 hasConcept C2778500429 @default.
- W3036682786 hasConcept C2780783641 @default.
- W3036682786 hasConcept C502942594 @default.
- W3036682786 hasConcept C55493867 @default.
- W3036682786 hasConcept C62112901 @default.
- W3036682786 hasConcept C71924100 @default.
- W3036682786 hasConcept C81729549 @default.
- W3036682786 hasConcept C84425145 @default.
- W3036682786 hasConcept C85265743 @default.
- W3036682786 hasConcept C86803240 @default.
- W3036682786 hasConcept C95444343 @default.
- W3036682786 hasConcept C96232424 @default.
- W3036682786 hasConcept C98274493 @default.
- W3036682786 hasConceptScore W3036682786C104317684 @default.
- W3036682786 hasConceptScore W3036682786C119157956 @default.
- W3036682786 hasConceptScore W3036682786C121608353 @default.
- W3036682786 hasConceptScore W3036682786C126322002 @default.
- W3036682786 hasConceptScore W3036682786C134018914 @default.
- W3036682786 hasConceptScore W3036682786C150903083 @default.
- W3036682786 hasConceptScore W3036682786C185592680 @default.
- W3036682786 hasConceptScore W3036682786C190283241 @default.
- W3036682786 hasConceptScore W3036682786C202751555 @default.
- W3036682786 hasConceptScore W3036682786C20418707 @default.