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- W3036685747 abstract "Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. Multiple etiologies are associated with preterm birth; however, 25% of preterm infants are born to a mother with intra-amniotic infection, most commonly due to invasion of the amniotic cavity by Ureaplasma species. Much research has focused on establishing a link between Ureaplasma species and adverse pregnancy/neonatal outcomes; however, little is known about the taxonomy of and host response against Ureaplasma species. Here, we applied a multifaceted approach, including human samples, in vivo models, and in vitro manipulations, to study the maternal-fetal immunobiology of Ureaplasma infection during pregnancy. Furthermore, we investigated the use of clarithromycin as a treatment for this infection. Our research provides translational knowledge that bolsters scientific understanding of Ureaplasma species as a cause of adverse pregnancy/neonatal outcomes and gives strong evidence for the use of clarithromycin as the recommended treatment for women intra-amniotically infected with Ureaplasma species." @default.
- W3036685747 created "2020-06-25" @default.
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- W3036685747 date "2020-06-30" @default.
- W3036685747 modified "2023-10-18" @default.
- W3036685747 title "Intra-Amniotic Infection with <i>Ureaplasma parvum</i> Causes Preterm Birth and Neonatal Mortality That Are Prevented by Treatment with Clarithromycin" @default.
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- W3036685747 doi "https://doi.org/10.1128/mbio.00797-20" @default.
- W3036685747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7315120" @default.
- W3036685747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32576673" @default.
- W3036685747 hasPublicationYear "2020" @default.
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