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- W3036689344 abstract "AllergyHouse dust mites (HDMs) are a major source of aeroallergens that trigger human allergic responses, including asthma. To characterize the heterogeneity of human CD4+ T helper (TH) cell responses to HDM antigens, Seumois et al. stimulated blood T cells with HDM peptides and isolated the freshly activated T cells for single-cell RNA sequencing. One TH cell subset was more frequent in individuals without HDM allergy. These cells may function to restrain allergic T helper 2 (TH2) cell responses. Individuals with both HDM allergy and asthma were enriched for interleukin-9–producing TH2 cells. These findings provide a basis for designing more precise approaches to thwart pathogenic TH cell responses contributing to allergic asthma.Sci. Immunol. 5 , eaba6087 (2020)." @default.
- W3036689344 created "2020-06-25" @default.
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- W3036689344 date "2020-06-18" @default.
- W3036689344 modified "2023-09-26" @default.
- W3036689344 title "Finding contributors to allergy control" @default.
- W3036689344 doi "https://doi.org/10.1126/science.368.6497.1324-t" @default.
- W3036689344 hasPublicationYear "2020" @default.
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