FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036692520> ?p ?o ?g. }

• W3036692520 endingPage "e6" @default.
• W3036692520 startingPage "e1" @default.
• W3036692520 abstract "Cystic fibrosis (CF) patients have reduced intestinal absorption of sterols and, despite enhanced endogenous synthesis, low plasma cholesterol. Lumacaftor/ivacaftor CFTR protein modulator therapy is used to improve the clinical outcome of CF patients homozygous for F508del mutation (homo-deltaF508). Aim of the study is to evaluate the cholesterol metabolism and hepatobiliary injury/function in adult homo-deltaF508 patients, before and after lumacaftor/ivacaftor treatment. Baseline parameters in homo-deltaF508 patients were compared to those in CF patients compound heterozygous for F508del mutation and another severe mutation (hetero-deltaF508).Cholesterol metabolism was evaluated measuring plasma phytosterols and cholestanol, as intestinal absorption markers, and lathosterol, as liver biosynthesis marker. We quantified serum vitamin E, as nutritional marker. We evaluated liver injury by aspartate aminotransferase (AST) and alanine transaminase (ALT), biliary injury by γ-glutamyltransferase (γGT) and AP, and the liver function by bilirubin and albumin.Before the treatment, homo-deltaF508 patients (n = 20) had significantly lower cholesterol and vitamin E compared to hetero-deltaF508 (n = 20). Lumacaftor/ivacaftor treatment caused: 1) further reduction of cholesterol; 2) lathosterol reduction, suggesting a normalization of endogenous synthesis; 3) cholestanol and vitamin E increment, indicating an improvement of lipid digestion/absorption. Vitamin E difference (after-before treatment) was positively associated to treatment months. Alkaline phosphatase was also reduced.These data suggest an effect of lumacaftor/ivacaftor on cholesterol metabolism and enterohepatic flux in CF patients. However, lumacaftor/ivacaftor does not promote the increase of cholesterol serum concentration that on the contrary declines. Further studies are needed to research the real mechanism causing this reduction." @default.
• W3036692520 created "2020-06-25" @default.
• W3036692520 creator A5015496746 @default.
• W3036692520 creator A5019281457 @default.
• W3036692520 creator A5029121399 @default.
• W3036692520 creator A5050025219 @default.
• W3036692520 creator A5053465388 @default.
• W3036692520 creator A5070022247 @default.
• W3036692520 creator A5072939037 @default.
• W3036692520 creator A5090434699 @default.
• W3036692520 date "2021-01-01" @default.
• W3036692520 modified "2023-10-12" @default.
• W3036692520 title "Lumacaftor/ivacaftor improves liver cholesterol metabolism but does not influence hypocholesterolemia in patients with cystic fibrosis" @default.
• W3036692520 cites W1977682490 @default.
• W3036692520 cites W1983069921 @default.
• W3036692520 cites W2007104703 @default.
• W3036692520 cites W2030675795 @default.
• W3036692520 cites W2033926035 @default.
• W3036692520 cites W2044260936 @default.
• W3036692520 cites W2081123852 @default.
• W3036692520 cites W2085861288 @default.
• W3036692520 cites W2115508558 @default.
• W3036692520 cites W2119848779 @default.
• W3036692520 cites W2122701100 @default.
• W3036692520 cites W2149161940 @default.
• W3036692520 cites W2160828663 @default.
• W3036692520 cites W2464178502 @default.
• W3036692520 cites W2754376246 @default.
• W3036692520 cites W2766423847 @default.
• W3036692520 cites W2782678117 @default.
• W3036692520 cites W2783106878 @default.
• W3036692520 cites W2795325821 @default.
• W3036692520 cites W2805859131 @default.
• W3036692520 cites W2890802504 @default.
• W3036692520 cites W2929291672 @default.
• W3036692520 cites W2973168004 @default.
• W3036692520 cites W2997674649 @default.
• W3036692520 cites W3006632303 @default.
• W3036692520 cites W4239226660 @default.
• W3036692520 doi "https://doi.org/10.1016/j.jcf.2020.06.015" @default.
• W3036692520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32586737" @default.
• W3036692520 hasPublicationYear "2021" @default.
• W3036692520 type Work @default.
• W3036692520 sameAs 3036692520 @default.
• W3036692520 citedByCount "10" @default.
• W3036692520 countsByYear W30366925202020 @default.
• W3036692520 countsByYear W30366925202021 @default.
• W3036692520 countsByYear W30366925202022 @default.
• W3036692520 countsByYear W30366925202023 @default.
• W3036692520 crossrefType "journal-article" @default.
• W3036692520 hasAuthorship W3036692520A5015496746 @default.
• W3036692520 hasAuthorship W3036692520A5019281457 @default.
• W3036692520 hasAuthorship W3036692520A5029121399 @default.
• W3036692520 hasAuthorship W3036692520A5050025219 @default.
• W3036692520 hasAuthorship W3036692520A5053465388 @default.
• W3036692520 hasAuthorship W3036692520A5070022247 @default.
• W3036692520 hasAuthorship W3036692520A5072939037 @default.
• W3036692520 hasAuthorship W3036692520A5090434699 @default.
• W3036692520 hasBestOaLocation W30366925201 @default.
• W3036692520 hasConcept C126322002 @default.
• W3036692520 hasConcept C134018914 @default.
• W3036692520 hasConcept C2776502428 @default.
• W3036692520 hasConcept C2776938444 @default.
• W3036692520 hasConcept C2778163477 @default.
• W3036692520 hasConcept C2778428886 @default.
• W3036692520 hasConcept C2778718757 @default.
• W3036692520 hasConcept C2778978578 @default.
• W3036692520 hasConcept C2780022283 @default.
• W3036692520 hasConcept C2781471481 @default.
• W3036692520 hasConcept C2992208098 @default.
• W3036692520 hasConcept C71924100 @default.
• W3036692520 hasConceptScore W3036692520C126322002 @default.
• W3036692520 hasConceptScore W3036692520C134018914 @default.
• W3036692520 hasConceptScore W3036692520C2776502428 @default.
• W3036692520 hasConceptScore W3036692520C2776938444 @default.
• W3036692520 hasConceptScore W3036692520C2778163477 @default.
• W3036692520 hasConceptScore W3036692520C2778428886 @default.
• W3036692520 hasConceptScore W3036692520C2778718757 @default.
• W3036692520 hasConceptScore W3036692520C2778978578 @default.
• W3036692520 hasConceptScore W3036692520C2780022283 @default.
• W3036692520 hasConceptScore W3036692520C2781471481 @default.
• W3036692520 hasConceptScore W3036692520C2992208098 @default.
• W3036692520 hasConceptScore W3036692520C71924100 @default.
• W3036692520 hasFunder F4320321781 @default.
• W3036692520 hasFunder F4320322218 @default.
• W3036692520 hasIssue "1" @default.
• W3036692520 hasLocation W30366925201 @default.
• W3036692520 hasLocation W30366925202 @default.
• W3036692520 hasOpenAccess W3036692520 @default.
• W3036692520 hasPrimaryLocation W30366925201 @default.
• W3036692520 hasRelatedWork W2036338268 @default.
• W3036692520 hasRelatedWork W2128475838 @default.
• W3036692520 hasRelatedWork W2409415991 @default.
• W3036692520 hasRelatedWork W2415708160 @default.
• W3036692520 hasRelatedWork W3168010511 @default.
• W3036692520 hasRelatedWork W3207946969 @default.
• W3036692520 hasRelatedWork W4281738576 @default.
• W3036692520 hasRelatedWork W4281771725 @default.

• next