FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036696096> ?p ?o ?g. }

• W3036696096 abstract "Abstract Background Dimorphism and biofilm formation are important virulence factors of some opportunistic human pathogenic yeasts. Such species commensally colonize skin or mucosal surfaces generally in yeast form, but under particular circumstances, convert into virulent hyphae and disseminate internal organs or cause mucocutaneous infections. The yeast-to-hypha shape-conversion promotes the development of a biofilm, a thick extracellular matrix with sessile cells within. The biofilm is capable to prevent the penetration of antifungal drugs, rendering the surviving biofilm-resident cells intrinsic sources of recurrent infections. The aim of this study was to evaluate the ability of silver nanoparticles (AgNPs) to attenuate the morphological switch and biofilm formation of several opportunistic pathogenic yeasts and to determine whether this feature depends on the nanoparticle size. Results AgNPs in three different sizes were prepared by chemical reduction approach and characterized by transmission electron microscopy, ultraviolet–visible spectroscopy and dynamic light scattering. The antifungal activity was evaluated by the microdilution method, the inhibitory capacity on biofilm formation and the biofilm degradation ability of differently sized AgNPs was assessed by viability assay. The morphological state of opportunistic pathogenic yeast cells in monoculture and in co-culture with human keratinocytes in the presence of AgNPs was examined by flow cytometry and scanning electron microscopy. All the three AgNPs inhibited the growth of the examined opportunistic pathogenic yeasts, nevertheless, AgNPs with the smallest diameter exhibited the most prominent toxic activities. AgNPs attenuated the biofilm formation in a nanoparticle size-dependent manner; however, their biofilm destruction capacity was negligible. AgNPs with the smallest size exerted the most significant effect on suppressing the morphological change of pathogens in monoculture as well as in a co-culture with keratinocytes. Conclusions Our results confirm that AgNPs are capable to hinder yeast-to-hypha morphological conversion and biofilm formation of opportunistic pathogens and this biological effect of AgNPs is size-dependent." @default.
• W3036696096 created "2020-06-25" @default.
• W3036696096 creator A5006255835 @default.
• W3036696096 creator A5007930515 @default.
• W3036696096 creator A5008227857 @default.
• W3036696096 creator A5012451310 @default.
• W3036696096 creator A5039693037 @default.
• W3036696096 creator A5043317787 @default.
• W3036696096 creator A5058609091 @default.
• W3036696096 creator A5062494556 @default.
• W3036696096 creator A5066166125 @default.
• W3036696096 creator A5066801662 @default.
• W3036696096 creator A5075348402 @default.
• W3036696096 creator A5076571987 @default.
• W3036696096 creator A5086462876 @default.
• W3036696096 date "2020-06-22" @default.
• W3036696096 modified "2023-10-14" @default.
• W3036696096 title "Size-dependent activity of silver nanoparticles on the morphological switch and biofilm formation of opportunistic pathogenic yeasts" @default.
• W3036696096 cites W1855860163 @default.
• W3036696096 cites W1969181076 @default.
• W3036696096 cites W1988490684 @default.
• W3036696096 cites W1989137900 @default.
• W3036696096 cites W1991399962 @default.
• W3036696096 cites W1995911703 @default.
• W3036696096 cites W2003564377 @default.
• W3036696096 cites W2008888079 @default.
• W3036696096 cites W2018554060 @default.
• W3036696096 cites W2029534110 @default.
• W3036696096 cites W2032040750 @default.
• W3036696096 cites W2040231410 @default.
• W3036696096 cites W2060789712 @default.
• W3036696096 cites W2061073363 @default.
• W3036696096 cites W2078330309 @default.
• W3036696096 cites W2083537528 @default.
• W3036696096 cites W2122727851 @default.
• W3036696096 cites W2137575148 @default.
• W3036696096 cites W2141740190 @default.
• W3036696096 cites W2149716740 @default.
• W3036696096 cites W2150911019 @default.
• W3036696096 cites W2150928501 @default.
• W3036696096 cites W2154044071 @default.
• W3036696096 cites W2161946971 @default.
• W3036696096 cites W2166552420 @default.
• W3036696096 cites W2167792529 @default.
• W3036696096 cites W2204142061 @default.
• W3036696096 cites W2252911663 @default.
• W3036696096 cites W2270336197 @default.
• W3036696096 cites W2427155427 @default.
• W3036696096 cites W2437719412 @default.
• W3036696096 cites W2525511112 @default.
• W3036696096 cites W2544508273 @default.
• W3036696096 cites W2582770299 @default.
• W3036696096 cites W2591084942 @default.
• W3036696096 cites W2767031614 @default.
• W3036696096 cites W2794188423 @default.
• W3036696096 cites W2794303017 @default.
• W3036696096 cites W2803328907 @default.
• W3036696096 cites W2811244359 @default.
• W3036696096 cites W2883789624 @default.
• W3036696096 cites W2888786190 @default.
• W3036696096 cites W2907990881 @default.
• W3036696096 cites W2911087946 @default.
• W3036696096 cites W2949036789 @default.
• W3036696096 cites W2955596531 @default.
• W3036696096 cites W2972586133 @default.
• W3036696096 doi "https://doi.org/10.1186/s12866-020-01858-9" @default.
• W3036696096 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7309973" @default.
• W3036696096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32571216" @default.
• W3036696096 hasPublicationYear "2020" @default.
• W3036696096 type Work @default.
• W3036696096 sameAs 3036696096 @default.
• W3036696096 citedByCount "21" @default.
• W3036696096 countsByYear W30366960962021 @default.
• W3036696096 countsByYear W30366960962022 @default.
• W3036696096 countsByYear W30366960962023 @default.
• W3036696096 crossrefType "journal-article" @default.
• W3036696096 hasAuthorship W3036696096A5006255835 @default.
• W3036696096 hasAuthorship W3036696096A5007930515 @default.
• W3036696096 hasAuthorship W3036696096A5008227857 @default.
• W3036696096 hasAuthorship W3036696096A5012451310 @default.
• W3036696096 hasAuthorship W3036696096A5039693037 @default.
• W3036696096 hasAuthorship W3036696096A5043317787 @default.
• W3036696096 hasAuthorship W3036696096A5058609091 @default.
• W3036696096 hasAuthorship W3036696096A5062494556 @default.
• W3036696096 hasAuthorship W3036696096A5066166125 @default.
• W3036696096 hasAuthorship W3036696096A5066801662 @default.
• W3036696096 hasAuthorship W3036696096A5075348402 @default.
• W3036696096 hasAuthorship W3036696096A5076571987 @default.
• W3036696096 hasAuthorship W3036696096A5086462876 @default.
• W3036696096 hasBestOaLocation W30366960961 @default.
• W3036696096 hasConcept C104317684 @default.
• W3036696096 hasConcept C155672457 @default.
• W3036696096 hasConcept C171250308 @default.
• W3036696096 hasConcept C192562407 @default.
• W3036696096 hasConcept C2779222958 @default.
• W3036696096 hasConcept C31499863 @default.
• W3036696096 hasConcept C523546767 @default.
• W3036696096 hasConcept C54355233 @default.
• W3036696096 hasConcept C55493867 @default.
• W3036696096 hasConcept C58123911 @default.

• next