FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036700017> ?p ?o ?g. }

• W3036700017 endingPage "1368" @default.
• W3036700017 startingPage "1355" @default.
• W3036700017 abstract "Deep brain stimulation of the subthalamic nucleus (STN) is an effective therapy for motor deficits in Parkinson's disease (PD), but commonly causes weight gain in late-phase PD patients probably by increasing feeding motivation. It is unclear how STN neurons represent and modulate feeding behavior in different internal states. In the present study, we found that feeding caused a robust activation of STN neurons in mice (GCaMP6 signal increased by 48.4% ± 7.2%, n = 9, P = 0.0003), and the extent varied with the size, valence, and palatability of food, but not with the repetition of feeding. Interestingly, energy deprivation increased the spontaneous firing rate (8.5 ± 1.5 Hz, n = 17, versus 4.7 ± 0.7 Hz, n = 18, P = 0.03) and the depolarization-induced spikes in STN neurons, as well as enhanced the STN responses to feeding. Optogenetic experiments revealed that stimulation and inhibition of STN neurons respectively reduced (by 11% ± 6%, n = 6, P = 0.02) and enhanced (by 36% ± 15%, n = 7, P = 0.03) food intake only in the dark phase. In conclusion, our results support the hypothesis that STN neurons are activated by feeding behavior, depending on energy homeostatic status and the palatability of food, and modulation of these neurons is sufficient to regulate food intake." @default.
• W3036700017 created "2020-06-25" @default.
• W3036700017 creator A5010911437 @default.
• W3036700017 creator A5014531364 @default.
• W3036700017 creator A5016491243 @default.
• W3036700017 creator A5034688120 @default.
• W3036700017 creator A5039517524 @default.
• W3036700017 creator A5067786455 @default.
• W3036700017 creator A5071109435 @default.
• W3036700017 creator A5086499340 @default.
• W3036700017 date "2020-06-21" @default.
• W3036700017 modified "2023-09-23" @default.
• W3036700017 title "Internal States Influence the Representation and Modulation of Food Intake by Subthalamic Neurons" @default.
• W3036700017 cites W1546234970 @default.
• W3036700017 cites W17025784 @default.
• W3036700017 cites W1815043210 @default.
• W3036700017 cites W1965460147 @default.
• W3036700017 cites W1972131474 @default.
• W3036700017 cites W1983048421 @default.
• W3036700017 cites W1993944609 @default.
• W3036700017 cites W1994997395 @default.
• W3036700017 cites W1999105066 @default.
• W3036700017 cites W2005197345 @default.
• W3036700017 cites W2013775087 @default.
• W3036700017 cites W2022561563 @default.
• W3036700017 cites W2034128529 @default.
• W3036700017 cites W2045473666 @default.
• W3036700017 cites W2046877885 @default.
• W3036700017 cites W2065485036 @default.
• W3036700017 cites W2083932518 @default.
• W3036700017 cites W2094289318 @default.
• W3036700017 cites W2098766452 @default.
• W3036700017 cites W2099153727 @default.
• W3036700017 cites W2099540110 @default.
• W3036700017 cites W2103018978 @default.
• W3036700017 cites W2106299403 @default.
• W3036700017 cites W2110744330 @default.
• W3036700017 cites W2126109999 @default.
• W3036700017 cites W2145049392 @default.
• W3036700017 cites W2158419631 @default.
• W3036700017 cites W2170908025 @default.
• W3036700017 cites W2172590986 @default.
• W3036700017 cites W2219452752 @default.
• W3036700017 cites W2339071900 @default.
• W3036700017 cites W2462607016 @default.
• W3036700017 cites W2469366252 @default.
• W3036700017 cites W2537018563 @default.
• W3036700017 cites W2623791013 @default.
• W3036700017 cites W2743950363 @default.
• W3036700017 cites W2755502992 @default.
• W3036700017 cites W2755641503 @default.
• W3036700017 cites W2784297496 @default.
• W3036700017 cites W2793969949 @default.
• W3036700017 cites W2809582891 @default.
• W3036700017 cites W2883912743 @default.
• W3036700017 cites W2889016666 @default.
• W3036700017 cites W2910766429 @default.
• W3036700017 cites W2982591362 @default.
• W3036700017 cites W3004289368 @default.
• W3036700017 doi "https://doi.org/10.1007/s12264-020-00533-3" @default.
• W3036700017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7674539" @default.
• W3036700017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32567027" @default.
• W3036700017 hasPublicationYear "2020" @default.
• W3036700017 type Work @default.
• W3036700017 sameAs 3036700017 @default.
• W3036700017 citedByCount "14" @default.
• W3036700017 countsByYear W30367000172020 @default.
• W3036700017 countsByYear W30367000172021 @default.
• W3036700017 countsByYear W30367000172022 @default.
• W3036700017 countsByYear W30367000172023 @default.
• W3036700017 crossrefType "journal-article" @default.
• W3036700017 hasAuthorship W3036700017A5010911437 @default.
• W3036700017 hasAuthorship W3036700017A5014531364 @default.
• W3036700017 hasAuthorship W3036700017A5016491243 @default.
• W3036700017 hasAuthorship W3036700017A5034688120 @default.
• W3036700017 hasAuthorship W3036700017A5039517524 @default.
• W3036700017 hasAuthorship W3036700017A5067786455 @default.
• W3036700017 hasAuthorship W3036700017A5071109435 @default.
• W3036700017 hasAuthorship W3036700017A5086499340 @default.
• W3036700017 hasBestOaLocation W30367000172 @default.
• W3036700017 hasConcept C126322002 @default.
• W3036700017 hasConcept C134018914 @default.
• W3036700017 hasConcept C15744967 @default.
• W3036700017 hasConcept C169760540 @default.
• W3036700017 hasConcept C172873279 @default.
• W3036700017 hasConcept C24998067 @default.
• W3036700017 hasConcept C2777319143 @default.
• W3036700017 hasConcept C2778542668 @default.
• W3036700017 hasConcept C2779134260 @default.
• W3036700017 hasConcept C2779734285 @default.
• W3036700017 hasConcept C31903555 @default.
• W3036700017 hasConcept C4141045 @default.
• W3036700017 hasConcept C50738837 @default.
• W3036700017 hasConcept C71924100 @default.
• W3036700017 hasConcept C86803240 @default.
• W3036700017 hasConceptScore W3036700017C126322002 @default.
• W3036700017 hasConceptScore W3036700017C134018914 @default.
• W3036700017 hasConceptScore W3036700017C15744967 @default.

• next