Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036700870> ?p ?o ?g. }
- W3036700870 endingPage "107935" @default.
- W3036700870 startingPage "107935" @default.
- W3036700870 abstract "Toxoplasma gondii is an important pathogen that causes serious public health problems. Currently, therapeutic drugs for toxoplasmosis cause serious side effects, and more effective and novel substances with relatively low toxicity are urgently needed. Ursolic acid (UA) has many properties that can be beneficial to healthcare. In this study, we synthesized eight series of UA derivatives bearing a tetrazole moiety and evaluated their anti-T. gondii activity in vitro using spiramycin as a positive control. Most of the synthesized derivatives exhibited better anti-T. gondii activity in vitro than UA, among which compound 12a exhibited the most potent anti-T. gondii activity. Furthermore, the results of biochemical parameter determination indicated that 12a effectively restored the normal body weight of mice infected with T. gondii, reduced hepatotoxicity, and exerted significant anti-oxidative effects compared with the findings for spiramycin. Additionally, our molecular docking study indicated that the synthesized compounds could act as potential inhibitors of T. gondii calcium-dependent protein kinase 1 (TgCDPK1), with 12a possessing strong affinity for TgCDPK1 via binding to the key amino acids GLU129 and TYR131." @default.
- W3036700870 created "2020-06-25" @default.
- W3036700870 creator A5014957302 @default.
- W3036700870 creator A5023604840 @default.
- W3036700870 creator A5049697325 @default.
- W3036700870 creator A5082311500 @default.
- W3036700870 creator A5085025467 @default.
- W3036700870 date "2020-09-01" @default.
- W3036700870 modified "2023-10-18" @default.
- W3036700870 title "Evaluation of ursolic acid derivatives with potential anti-Toxoplasma gondii activity" @default.
- W3036700870 cites W1837086769 @default.
- W3036700870 cites W1964283685 @default.
- W3036700870 cites W1983310681 @default.
- W3036700870 cites W1995451133 @default.
- W3036700870 cites W1995515299 @default.
- W3036700870 cites W2000497556 @default.
- W3036700870 cites W2043487102 @default.
- W3036700870 cites W2045253964 @default.
- W3036700870 cites W2053542703 @default.
- W3036700870 cites W2056512550 @default.
- W3036700870 cites W2063319215 @default.
- W3036700870 cites W2064921662 @default.
- W3036700870 cites W2072374071 @default.
- W3036700870 cites W2120260995 @default.
- W3036700870 cites W2132773724 @default.
- W3036700870 cites W2150589746 @default.
- W3036700870 cites W2157304247 @default.
- W3036700870 cites W2177422462 @default.
- W3036700870 cites W2299192096 @default.
- W3036700870 cites W2555505930 @default.
- W3036700870 cites W2584655547 @default.
- W3036700870 cites W2621134676 @default.
- W3036700870 cites W2621896048 @default.
- W3036700870 cites W2736270963 @default.
- W3036700870 cites W2742319020 @default.
- W3036700870 cites W2755067926 @default.
- W3036700870 cites W2756354275 @default.
- W3036700870 cites W2767210872 @default.
- W3036700870 cites W2774310375 @default.
- W3036700870 cites W2792875175 @default.
- W3036700870 cites W2802006489 @default.
- W3036700870 cites W2802257913 @default.
- W3036700870 cites W2887023542 @default.
- W3036700870 cites W2891774360 @default.
- W3036700870 cites W2902533894 @default.
- W3036700870 cites W2904214782 @default.
- W3036700870 cites W2922311460 @default.
- W3036700870 cites W2935812344 @default.
- W3036700870 cites W2939123287 @default.
- W3036700870 cites W2945607575 @default.
- W3036700870 cites W2959972941 @default.
- W3036700870 cites W2965134608 @default.
- W3036700870 doi "https://doi.org/10.1016/j.exppara.2020.107935" @default.
- W3036700870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32569599" @default.
- W3036700870 hasPublicationYear "2020" @default.
- W3036700870 type Work @default.
- W3036700870 sameAs 3036700870 @default.
- W3036700870 citedByCount "5" @default.
- W3036700870 countsByYear W30367008702021 @default.
- W3036700870 countsByYear W30367008702022 @default.
- W3036700870 countsByYear W30367008702023 @default.
- W3036700870 crossrefType "journal-article" @default.
- W3036700870 hasAuthorship W3036700870A5014957302 @default.
- W3036700870 hasAuthorship W3036700870A5023604840 @default.
- W3036700870 hasAuthorship W3036700870A5049697325 @default.
- W3036700870 hasAuthorship W3036700870A5082311500 @default.
- W3036700870 hasAuthorship W3036700870A5085025467 @default.
- W3036700870 hasConcept C159047783 @default.
- W3036700870 hasConcept C159654299 @default.
- W3036700870 hasConcept C185592680 @default.
- W3036700870 hasConcept C202751555 @default.
- W3036700870 hasConcept C203014093 @default.
- W3036700870 hasConcept C2776568683 @default.
- W3036700870 hasConcept C2778062946 @default.
- W3036700870 hasConcept C2778128430 @default.
- W3036700870 hasConcept C2779172262 @default.
- W3036700870 hasConcept C2779513101 @default.
- W3036700870 hasConcept C2780206985 @default.
- W3036700870 hasConcept C501593827 @default.
- W3036700870 hasConcept C55493867 @default.
- W3036700870 hasConcept C59822182 @default.
- W3036700870 hasConcept C71240020 @default.
- W3036700870 hasConcept C86803240 @default.
- W3036700870 hasConcept C98274493 @default.
- W3036700870 hasConceptScore W3036700870C159047783 @default.
- W3036700870 hasConceptScore W3036700870C159654299 @default.
- W3036700870 hasConceptScore W3036700870C185592680 @default.
- W3036700870 hasConceptScore W3036700870C202751555 @default.
- W3036700870 hasConceptScore W3036700870C203014093 @default.
- W3036700870 hasConceptScore W3036700870C2776568683 @default.
- W3036700870 hasConceptScore W3036700870C2778062946 @default.
- W3036700870 hasConceptScore W3036700870C2778128430 @default.
- W3036700870 hasConceptScore W3036700870C2779172262 @default.
- W3036700870 hasConceptScore W3036700870C2779513101 @default.
- W3036700870 hasConceptScore W3036700870C2780206985 @default.
- W3036700870 hasConceptScore W3036700870C501593827 @default.
- W3036700870 hasConceptScore W3036700870C55493867 @default.
- W3036700870 hasConceptScore W3036700870C59822182 @default.