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• W3036701447 abstract "Significance The use of BRAF V600E-selective inhibitor dabrafenib and MEK inhibitor trametinib is a standard first-line treatment for human cancers harboring BRAF V600E. However, drug resistance/tumor recurrence is common with this treatment and the outcomes are unpredictable. We demonstrate here that dabrafenib and trametinib robustly induce cell apoptosis and hence abolishment of growth/regrowth of cancers harboring both BRAF V600E and TERT promoter mutations with little effect in cells/tumors harboring only BRAF V600E. Thus, TERT promoter mutation, by governing the apoptotic and hence therapeutic sensitivities of BRAF-mutant cancer cells to BRAF/MEK inhibitors, may potentially be useful in helping patient selection for the inhibitor treatment and predicting therapeutic outcomes." @default.
• W3036701447 created "2020-06-25" @default.
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• W3036701447 date "2020-06-19" @default.
• W3036701447 modified "2023-09-30" @default.
• W3036701447 title "<i>TERT</i> promoter mutation determines apoptotic and therapeutic responses of <i>BRAF</i> -mutant cancers to BRAF and MEK inhibitors: Achilles Heel" @default.
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• W3036701447 doi "https://doi.org/10.1073/pnas.2004707117" @default.
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