FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036701783> ?p ?o ?g. }

• W3036701783 abstract "Abstract Funding Acknowledgements Investigator Sponsored Research grant from Boston Scientific Introduction Irrigated catheters are the standard tool for radiofrequency (RF) ablation in the left atrium and ventricles. However, pathological studies of irrigated RF lesions show a tear-drop shape, with the widest diameter some depth below the endocardial surface and relative endocardial sparing. This requires overlap of lesions to achieve contiguity at the endocardial surface. There has been little investigation into the effect of altering irrigation rate on lesion shape and volume. Purpose To test the hypothesis that varying the irrigation flow rate would optimise lesion shape by minimising endocardial sparing while maintaining lesion depth. Methods In an ex vivo animal heart model, irrigated ablation lesions were performed in porcine ventricular tissue at 30W using an Intellatip MiFi OI catheter with 5 different irrigation protocols: A. fixed rate (30ml/min); B. continuous reduction (30 to 2ml/min over 30s); C. continuous increase (2 to 30ml/min over 30s); D. stepwise reduction (30ml/min (10s) to 16ml/min (10s) to 2ml/min (10s)); E. stepwise increase (2ml/min (10s) to 16ml/min (10s) to 30ml/min (10s). Contact force (10g) and ablation duration (30s) were constant. Steam pops during ablation were recorded. Tissue sections were stained with triphenyltetrazolium chloride (TTC) after ablation to allow accurate measurement of lesion boundaries. Surface diameter, lesion depth, maximum diameter, and depth at maximum diameter were measured using Vernier Calipers to calculate lesion volume. Pictures of lesions were analysed further by ImageJ software to measure the degree of endocardial sparing. The optimal protocol was further tested against fixed-rate irrigation at 20W – 40W. Results 10-20 lesions were performed for each irrigation protocol. Of the 4 experimental protocols, continuous reduction (protocol B) resulted in the most optimal lesion shape (Figure). With this protocol, endocardial sparing area was significantly reduced compared to fixed-rate irrigation (1.61 vs. 2.64mm2, P &lt; 0.0001), with a trend towards an increase in surface diameter (9.25 vs. 8.46mm, P = 0.08). There was no significant difference in lesion depth (5.35 vs. 4.77mm), lesion volume (374 vs. 332mm3) or maximum diameter (10.3 vs. 10.8mm). Steam pop occurred in 1 of 20 (5%) lesions in each of protocols A and B. Significantly reduced endocardial sparing with preserved volume/depth was consistent for continuous reduction when compared to fixed-rate irrigation across power settings of 20W (17ml/min), 30 W (17ml/min or 30ml/min) and 40W (30ml/min) (P &lt; 0.0001). Conclusions Continuous reduction in irrigation flow rate from 30 to 2ml/min during irrigated RF ablation results in reduced endocardial sparing with preserved lesion depth and volume when compared to fixed-rate irrigation across power settings of 20 – 40W. This may allow for greater lesion spacing while maintaining endocardial contiguity and merits further investigation to improve irrigated RF ablation efficiency. Abstract Figure" @default.
• W3036701783 created "2020-06-25" @default.
• W3036701783 creator A5034156657 @default.
• W3036701783 creator A5062769618 @default.
• W3036701783 creator A5064491988 @default.
• W3036701783 creator A5076457441 @default.
• W3036701783 creator A5083097413 @default.
• W3036701783 creator A5084250152 @default.
• W3036701783 date "2020-06-01" @default.
• W3036701783 modified "2023-09-23" @default.
• W3036701783 title "652The effect of varying irrigation flow rate during irrigated radiofrequency ablation on optimising lesion shape" @default.
• W3036701783 doi "https://doi.org/10.1093/europace/euaa162.234" @default.
• W3036701783 hasPublicationYear "2020" @default.
• W3036701783 type Work @default.
• W3036701783 sameAs 3036701783 @default.
• W3036701783 citedByCount "0" @default.
• W3036701783 crossrefType "journal-article" @default.
• W3036701783 hasAuthorship W3036701783A5034156657 @default.
• W3036701783 hasAuthorship W3036701783A5062769618 @default.
• W3036701783 hasAuthorship W3036701783A5064491988 @default.
• W3036701783 hasAuthorship W3036701783A5076457441 @default.
• W3036701783 hasAuthorship W3036701783A5083097413 @default.
• W3036701783 hasAuthorship W3036701783A5084250152 @default.
• W3036701783 hasConcept C126838900 @default.
• W3036701783 hasConcept C136229726 @default.
• W3036701783 hasConcept C141071460 @default.
• W3036701783 hasConcept C164705383 @default.
• W3036701783 hasConcept C2777377203 @default.
• W3036701783 hasConcept C2778902805 @default.
• W3036701783 hasConcept C2781156865 @default.
• W3036701783 hasConcept C2781267111 @default.
• W3036701783 hasConcept C2989005 @default.
• W3036701783 hasConcept C71924100 @default.
• W3036701783 hasConceptScore W3036701783C126838900 @default.
• W3036701783 hasConceptScore W3036701783C136229726 @default.
• W3036701783 hasConceptScore W3036701783C141071460 @default.
• W3036701783 hasConceptScore W3036701783C164705383 @default.
• W3036701783 hasConceptScore W3036701783C2777377203 @default.
• W3036701783 hasConceptScore W3036701783C2778902805 @default.
• W3036701783 hasConceptScore W3036701783C2781156865 @default.
• W3036701783 hasConceptScore W3036701783C2781267111 @default.
• W3036701783 hasConceptScore W3036701783C2989005 @default.
• W3036701783 hasConceptScore W3036701783C71924100 @default.
• W3036701783 hasLocation W30367017831 @default.
• W3036701783 hasOpenAccess W3036701783 @default.
• W3036701783 hasPrimaryLocation W30367017831 @default.
• W3036701783 hasRelatedWork W11161009 @default.
• W3036701783 hasRelatedWork W16798664 @default.
• W3036701783 hasRelatedWork W20204992 @default.
• W3036701783 hasRelatedWork W20268724 @default.
• W3036701783 hasRelatedWork W3040571 @default.
• W3036701783 hasRelatedWork W4583761 @default.
• W3036701783 hasRelatedWork W550143 @default.
• W3036701783 hasRelatedWork W7878638 @default.
• W3036701783 hasRelatedWork W14248210 @default.
• W3036701783 hasRelatedWork W5909635 @default.
• W3036701783 isParatext "false" @default.
• W3036701783 isRetracted "false" @default.
• W3036701783 magId "3036701783" @default.
• W3036701783 workType "article" @default.