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- W3036706429 abstract "Many members of nontuberculous mycobacteria (NTM) are opportunistic pathogens causing several infections in animals. The incidence of NTM infections and emergence of drug-resistant NTM strains are rising worldwide, emphasizing the need to develop novel anti-NTM drugs. The present study is aimed to identify broad-spectrum drug targets in NTM using a comparative genomics approach. The study identified 537 core proteins in NTM of which 45 were pathogen specific and essential for the survival of pathogens. Furthermore, druggability analysis indicated that 15 were druggable among those 45 proteins. These 15 proteins, which were core proteins, pathogen-specific, essential, and druggable, were considered as potential broad-spectrum candidates. Based on their locations in cytoplasm and membrane, targets were classified as drug and vaccine targets. The identified 15 targets were different enzymes, carrier proteins, transcriptional regulator, two-component system protein, ribosomal, and binding proteins. The identified targets could further be utilized by researchers to design inhibitors for the discovery of antimicrobial agents." @default.
- W3036706429 created "2020-06-25" @default.
- W3036706429 creator A5004071605 @default.
- W3036706429 creator A5012287683 @default.
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- W3036706429 creator A5037656991 @default.
- W3036706429 creator A5047546703 @default.
- W3036706429 creator A5059498160 @default.
- W3036706429 creator A5064832018 @default.
- W3036706429 date "2021-02-01" @default.
- W3036706429 modified "2023-10-01" @default.
- W3036706429 title "A Comparative Genomics Approach for Shortlisting Broad-Spectrum Drug Targets in Nontuberculous Mycobacteria" @default.
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