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- W3036707022 abstract "Understanding how context (e.g., host species, environmental conditions) drives disease susceptibility is an essential goal of disease ecology. We hypothesized that in bat white-nose syndrome (WNS), species-specific host–pathogen interactions may partly explain varying disease outcomes among host species. We characterized bat and pathogen transcriptomes in paired samples of lesion-positive and lesion-negative wing tissue from bats infected with Pseudogymnoascus destructans in three parallel experiments. The first two experiments analyzed samples collected from the susceptible Nearctic Myotis lucifugus and the less-susceptible Nearctic Eptesicus fuscus, following experimental infection and hibernation in captivity under controlled conditions. The third experiment applied the same analyses to paired samples from infected, free-ranging Myotis myotis, a less susceptible, Palearctic species, following natural infection and hibernation (n = 8 sample pairs/species). Gene expression by P. destructans was similar among the three host species despite varying environmental conditions among the three experiments and was similar within each host species between saprophytic contexts (superficial growth on wings) and pathogenic contexts (growth in lesions on the same wings). In contrast, we observed qualitative variation in host response: M. lucifugus and M. myotis exhibited systemic responses to infection, while E. fuscus up-regulated a remarkably localized response. Our results suggest potential phylogenetic determinants of response to WNS and can inform further studies of context-dependent host–pathogen interactions." @default.
- W3036707022 created "2020-06-25" @default.
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- W3036707022 date "2020-06-17" @default.
- W3036707022 modified "2023-09-30" @default.
- W3036707022 title "Transcriptional host–pathogen responses of <i>Pseudogymnoascus destructans</i> and three species of bats with white-nose syndrome" @default.
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- W3036707022 cites W1951724000 @default.
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- W3036707022 cites W1988959606 @default.
- W3036707022 cites W1992527642 @default.
- W3036707022 cites W1998045625 @default.
- W3036707022 cites W1999574084 @default.
- W3036707022 cites W2010682046 @default.
- W3036707022 cites W2011807383 @default.
- W3036707022 cites W2037031097 @default.
- W3036707022 cites W2039160908 @default.
- W3036707022 cites W2045843097 @default.
- W3036707022 cites W2053152296 @default.
- W3036707022 cites W2058127090 @default.
- W3036707022 cites W2061521827 @default.
- W3036707022 cites W2079220734 @default.
- W3036707022 cites W2080709723 @default.
- W3036707022 cites W2082878774 @default.
- W3036707022 cites W2094684530 @default.
- W3036707022 cites W2098394908 @default.
- W3036707022 cites W2102278945 @default.
- W3036707022 cites W2103148772 @default.
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- W3036707022 cites W2114104545 @default.
- W3036707022 cites W2125011614 @default.
- W3036707022 cites W2126419817 @default.
- W3036707022 cites W2131271579 @default.
- W3036707022 cites W2137161803 @default.
- W3036707022 cites W2138207763 @default.
- W3036707022 cites W2139710906 @default.
- W3036707022 cites W2145741106 @default.
- W3036707022 cites W2155274508 @default.
- W3036707022 cites W2156564520 @default.
- W3036707022 cites W2164858554 @default.
- W3036707022 cites W2171036736 @default.
- W3036707022 cites W2204881968 @default.
- W3036707022 cites W2233734995 @default.
- W3036707022 cites W2253391963 @default.
- W3036707022 cites W2300386459 @default.
- W3036707022 cites W2407247987 @default.
- W3036707022 cites W2473958552 @default.
- W3036707022 cites W2520184432 @default.
- W3036707022 cites W2529725155 @default.
- W3036707022 cites W2536434144 @default.
- W3036707022 cites W2549976854 @default.
- W3036707022 cites W2560501683 @default.
- W3036707022 cites W2622035604 @default.
- W3036707022 cites W2625960863 @default.
- W3036707022 cites W2735019061 @default.
- W3036707022 cites W2740761923 @default.
- W3036707022 cites W2741526654 @default.
- W3036707022 cites W2742071918 @default.
- W3036707022 cites W2748394798 @default.
- W3036707022 cites W2772276010 @default.
- W3036707022 cites W2791071327 @default.
- W3036707022 cites W2802727510 @default.
- W3036707022 cites W2804939169 @default.
- W3036707022 cites W2809110442 @default.
- W3036707022 cites W2845591014 @default.
- W3036707022 cites W2885787954 @default.
- W3036707022 cites W2888972978 @default.
- W3036707022 cites W2895801917 @default.
- W3036707022 cites W2902416317 @default.
- W3036707022 cites W2916097502 @default.
- W3036707022 cites W2943795006 @default.
- W3036707022 cites W2950580334 @default.
- W3036707022 cites W2950660559 @default.
- W3036707022 cites W2951257985 @default.
- W3036707022 cites W2961201202 @default.
- W3036707022 cites W2972624732 @default.
- W3036707022 cites W3004227146 @default.
- W3036707022 cites W4250359879 @default.
- W3036707022 doi "https://doi.org/10.1080/21505594.2020.1768018" @default.
- W3036707022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7549942" @default.
- W3036707022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32552222" @default.
- W3036707022 hasPublicationYear "2020" @default.
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