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• W3036712529 abstract "ABSTRACT Myelination increases axonal conduction velocity and contributes to neural circuit function. Consequently, myelin disruption causes behavioral and cognitive defects. Myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination focused primarily on these cells. However, axons of inhibitory neurons are also myelinated (Micheva et al., 2016), but the effects of myelin on inhibitory circuits are unknown. We thus studied mice that have mild hypomyelination due to loss of oligodendrocyte ErbB receptor signaling, focusing on primary auditory cortex (A1). We found that mutant mice have reduced A1 myelin and inhibitory connections to L2/3 neurons without affecting excitatory inputs, thus altering excitatory/inhibitory balance. These effects are not associated with altered expression of GABAergic and glutamatergic synaptic components, but with reduced parvalbumin-positive (PV + ) neuron density and PV mRNA levels. These results demonstrate that mild hypomyelination can impact cortical neuronal networks, reducing inhibitory activity, and shifting networks towards excitation. Impact Statement Mild hypomyelination alters excitatory/inhibitory balance in the primary auditory cortex by reducing the number of parvalbumin-positive interneurons and reducing inhibition." @default.
• W3036712529 created "2020-06-25" @default.
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• W3036712529 date "2020-06-24" @default.
• W3036712529 modified "2023-10-17" @default.
• W3036712529 title "Hypomyelination leads to alterations in inhibitory function and parvalbumin-positive neuron density in auditory cortex" @default.
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• W3036712529 doi "https://doi.org/10.1101/2020.06.23.167833" @default.
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