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- W3036720502 endingPage "4325" @default.
- W3036720502 startingPage "4325" @default.
- W3036720502 abstract "Lung cancer is the most frequent cancer with an aggressive clinical course and high mortality rates. Most cases are diagnosed at advanced stages when treatment options are limited and the efficacy of chemotherapy is poor. The disease has a complex and heterogeneous background with non-small-cell lung cancer (NSCLC) accounting for 85% of patients and lung adenocarcinoma being the most common histological subtype. Almost 30% of adenocarcinomas of the lung are driven by an activating Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation. The ability to inhibit the oncogenic KRAS has been the holy grail of cancer research and the search for inhibitors is immensely ongoing as KRAS-mutated tumors are among the most aggressive and refractory to treatment. Therapeutic strategies tailored for KRAS+ NSCLC rely on the blockage of KRAS functional output, cellular dependencies, metabolic features, KRAS membrane associations, direct targeting of KRAS and immunotherapy. In this review, we provide an update on the most recent advances in anti-KRAS therapy for lung tumors with mechanistic insights into biological diversity and potential clinical implications." @default.
- W3036720502 created "2020-06-25" @default.
- W3036720502 creator A5045621470 @default.
- W3036720502 creator A5068007678 @default.
- W3036720502 creator A5084484318 @default.
- W3036720502 date "2020-06-17" @default.
- W3036720502 modified "2023-10-18" @default.
- W3036720502 title "Targeting KRAS Mutant Non-Small-Cell Lung Cancer: Past, Present and Future" @default.
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