FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036723504> ?p ?o ?g. }

• W3036723504 abstract "microRNAs (miRNAs) are conserved non-coding small nucleotide molecules found in nearly all species and breastmilk. miRNAs present in breastmilk are very stable to freeze-thaw, RNase treatment, and low pH as they are protected inside exosomes. They are involved in regulating several physiologic and pathologic processes, including immunologic pathways, and we have demonstrated better immune response to vaccines in piglets fed with human milk (HM) in comparison to dairy-based formula (MF). To understand if neonatal diet impacts circulatory miRNA expression, serum miRNA expression was evaluated in piglets fed HM or MF while on their neonatal diet at postnatal day (PND) 21 and post-weaning to solid diet PND 35 and 51. MF fed piglets showed increased expression of 14 miRNAs and decreased expression of 10 miRNAs, relative to HM fed piglets at PND 21. At PND 35, 9 miRNAs were downregulated in the MF compared to the HM group. At PND 51, 10 miRNAs were decreased and 17 were increased in the MF relative to HM suggesting the persistent effect of neonatal diet. miR-148 and miR-181 were decreased in MF compared to HM at PND 21. Let-7 was decreased at PND 35 while miR-199a and miR-199b were increased at PND 51 in MF compared to HM. Pathway analysis suggested that many of the miRNAs are involved in immune function. In conclusion, we observed differential expression of blood miRNAs at both PND 21 and PND 51. miRNA found in breast milk were decreased in the serum of the MF group, suggesting that diet impacts circulating miRNA profiles at PND 21. The miRNAs continue to be altered at PND 51 suggesting a persistent effect of the neonatal diet. The sources of miRNAs in circulation need to be evaluated, as the piglets were fed the same solid diet leading up to PND 51 collections. In conclusion, the HM diet appears to have an immediate and persistent effect on the miRNA profile and likely regulates the pathways that impact the immune system and pose benefits to breastfed infants." @default.
• W3036723504 created "2020-06-25" @default.
• W3036723504 creator A5025160415 @default.
• W3036723504 creator A5042071159 @default.
• W3036723504 creator A5048204487 @default.
• W3036723504 creator A5053580420 @default.
• W3036723504 creator A5060744783 @default.
• W3036723504 creator A5068606530 @default.
• W3036723504 creator A5084758555 @default.
• W3036723504 creator A5086417088 @default.
• W3036723504 date "2020-06-23" @default.
• W3036723504 modified "2023-10-14" @default.
• W3036723504 title "Neonatal Diet Impacts Circulatory miRNA Profile in a Porcine Model" @default.
• W3036723504 cites W1660892562 @default.
• W3036723504 cites W1927296860 @default.
• W3036723504 cites W1965152588 @default.
• W3036723504 cites W1968839521 @default.
• W3036723504 cites W1994645662 @default.
• W3036723504 cites W1999319492 @default.
• W3036723504 cites W2005440577 @default.
• W3036723504 cites W2014946489 @default.
• W3036723504 cites W2025567420 @default.
• W3036723504 cites W2026452111 @default.
• W3036723504 cites W2038303173 @default.
• W3036723504 cites W2047563805 @default.
• W3036723504 cites W2058670430 @default.
• W3036723504 cites W2059382687 @default.
• W3036723504 cites W2060872094 @default.
• W3036723504 cites W2064147974 @default.
• W3036723504 cites W2073516129 @default.
• W3036723504 cites W2076556926 @default.
• W3036723504 cites W2082414447 @default.
• W3036723504 cites W2097278383 @default.
• W3036723504 cites W2107018762 @default.
• W3036723504 cites W2109480277 @default.
• W3036723504 cites W2114104545 @default.
• W3036723504 cites W2115829148 @default.
• W3036723504 cites W2129551032 @default.
• W3036723504 cites W2129802808 @default.
• W3036723504 cites W2130086018 @default.
• W3036723504 cites W2130116522 @default.
• W3036723504 cites W2151577520 @default.
• W3036723504 cites W2152656267 @default.
• W3036723504 cites W2167875873 @default.
• W3036723504 cites W2208371567 @default.
• W3036723504 cites W2335952805 @default.
• W3036723504 cites W2432815617 @default.
• W3036723504 cites W2549746211 @default.
• W3036723504 cites W2576385788 @default.
• W3036723504 cites W2694847810 @default.
• W3036723504 cites W2733152565 @default.
• W3036723504 cites W2738012346 @default.
• W3036723504 cites W2782841700 @default.
• W3036723504 cites W2787160317 @default.
• W3036723504 cites W2788744057 @default.
• W3036723504 cites W2793234924 @default.
• W3036723504 cites W2796215094 @default.
• W3036723504 cites W2797008586 @default.
• W3036723504 cites W2804596631 @default.
• W3036723504 cites W2806440359 @default.
• W3036723504 cites W2810554310 @default.
• W3036723504 cites W2892598048 @default.
• W3036723504 cites W2898336829 @default.
• W3036723504 cites W2903417533 @default.
• W3036723504 cites W2904784650 @default.
• W3036723504 cites W2907925587 @default.
• W3036723504 cites W2937300608 @default.
• W3036723504 cites W2949335118 @default.
• W3036723504 cites W2950985970 @default.
• W3036723504 cites W2964574458 @default.
• W3036723504 cites W2966376335 @default.
• W3036723504 cites W2972985545 @default.
• W3036723504 cites W2990615413 @default.
• W3036723504 cites W2998598029 @default.
• W3036723504 cites W328409768 @default.
• W3036723504 cites W4212888212 @default.
• W3036723504 cites W824207155 @default.
• W3036723504 doi "https://doi.org/10.3389/fimmu.2020.01240" @default.
• W3036723504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7324749" @default.
• W3036723504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32655560" @default.
• W3036723504 hasPublicationYear "2020" @default.
• W3036723504 type Work @default.
• W3036723504 sameAs 3036723504 @default.
• W3036723504 citedByCount "4" @default.
• W3036723504 countsByYear W30367235042021 @default.
• W3036723504 countsByYear W30367235042022 @default.
• W3036723504 countsByYear W30367235042023 @default.
• W3036723504 crossrefType "journal-article" @default.
• W3036723504 hasAuthorship W3036723504A5025160415 @default.
• W3036723504 hasAuthorship W3036723504A5042071159 @default.
• W3036723504 hasAuthorship W3036723504A5048204487 @default.
• W3036723504 hasAuthorship W3036723504A5053580420 @default.
• W3036723504 hasAuthorship W3036723504A5060744783 @default.
• W3036723504 hasAuthorship W3036723504A5068606530 @default.
• W3036723504 hasAuthorship W3036723504A5084758555 @default.
• W3036723504 hasAuthorship W3036723504A5086417088 @default.
• W3036723504 hasBestOaLocation W30367235041 @default.
• W3036723504 hasConcept C104317684 @default.
• W3036723504 hasConcept C126322002 @default.
• W3036723504 hasConcept C134018914 @default.

• next