Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036758424> ?p ?o ?g. }
- W3036758424 abstract "Ovarian Cancer (OC) is currently difficult to cure, mainly due to its late detection and the advanced state of the disease at the time of diagnosis. Therefore, conventional treatments such as debulking surgery and combination chemotherapy are rarely able to control progression of the tumour, and relapses are frequent. Alternative therapies are currently being evaluated, including immunotherapy and advanced T cell-based therapy. In the present review, we will focus on a description of those Chimeric Antigen Receptors (CARs) that have been validated in the laboratory or are being tested in the clinic. Numerous target antigens have been defined due to the identification of OC biomarkers, and many are being used as CAR targets. We provide an exhaustive list of these constructs and their current status. Despite being innovative and efficient, the OC-specific CARs face a barrier to their clinical efficacy: the tumour microenvironment (TME). Indeed, effector cells expressing CARs have been shown to be severely inhibited, rendering the CAR T cells useless once at the tumour site. Herein, we give a thorough description of the highly immunosuppressive OC TME and present recent studies and innovations that have enabled CAR T cells to counteract this negative environment and to destroy tumours." @default.
- W3036758424 created "2020-06-25" @default.
- W3036758424 creator A5023792974 @default.
- W3036758424 creator A5024559548 @default.
- W3036758424 creator A5078974536 @default.
- W3036758424 creator A5091253691 @default.
- W3036758424 date "2020-09-30" @default.
- W3036758424 modified "2023-09-26" @default.
- W3036758424 title "SJI 2020 special issue: A catalogue of Ovarian Cancer targets for CAR therapy" @default.
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