FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036775154> ?p ?o ?g. }

• W3036775154 endingPage "1133" @default.
• W3036775154 startingPage "1121" @default.
• W3036775154 abstract "BACKGROUND Coordinated calcium influx upon neuronal depolarization activates pathways that phosphorylate CaMKII, ERKs, and the transcription factor CREB and, therefore, expression of pro-survival and neuroprotective genes. Recent evidence indicates that amyloid-β protein precursor (AβPP) is trafficked to synapses and promotes their formation. At the synapse, AβPP interacts with synaptic proteins involved in vesicle exocytosis and affects calcium channel function. OBJECTIVE Herein, we examined the role of AβPP in depolarization-induced calcium-mediated signaling using acute cerebral slices from wild-type C57bl/6 mice and AβPP-/- C57bl/6 mice. METHODS Depolarization of acute cerebral slices from wild-type C57bl/6 and AβPP-/- C57bl/6 mice was used to induce synaptic signaling. Protein levels were examined by western blot and calcium dynamics were assessed using primary neuronal cultures. RESULTS In the absence of AβPP, decreased pCaMKII and pERKs levels were observed. This decrease was sensitive to the inhibition of N- and P/Q-type Voltage Gated Calcium Channels (N- and P/Q-VGCCs) by ω-conotoxin GVIA and ω-conotoxin MVIIC, respectively, but not to inhibition of L-type VGCCs by nifedipine. However, the absence of AβPP did not result in a statistically significant decrease of pCREB, which is a known substrate of pERKs. Finally, using calcium imaging, we found that down regulation of AβPP in cortical neurons results in a decreased response to depolarization and altered kinetics of calcium response. CONCLUSION AβPP regulates synaptic activity-mediated neuronal signaling by affecting N- and P/Q-VGCCs." @default.
• W3036775154 created "2020-06-25" @default.
• W3036775154 creator A5007637621 @default.
• W3036775154 creator A5062475586 @default.
• W3036775154 creator A5072246865 @default.
• W3036775154 date "2020-08-04" @default.
• W3036775154 modified "2023-09-24" @default.
• W3036775154 title "Amyloid-β Protein Precursor Regulates Depolarization-Induced Calcium-Mediated Synaptic Signaling in Brain Slices" @default.
• W3036775154 cites W1543551659 @default.
• W3036775154 cites W1662601966 @default.
• W3036775154 cites W1704367191 @default.
• W3036775154 cites W1951572307 @default.
• W3036775154 cites W1963966727 @default.
• W3036775154 cites W1970049338 @default.
• W3036775154 cites W1977715568 @default.
• W3036775154 cites W1981008691 @default.
• W3036775154 cites W1990752558 @default.
• W3036775154 cites W1998140650 @default.
• W3036775154 cites W1999204642 @default.
• W3036775154 cites W2000383563 @default.
• W3036775154 cites W2003320905 @default.
• W3036775154 cites W2019593939 @default.
• W3036775154 cites W2027140832 @default.
• W3036775154 cites W2034998738 @default.
• W3036775154 cites W2038958366 @default.
• W3036775154 cites W2040107178 @default.
• W3036775154 cites W2041727630 @default.
• W3036775154 cites W2048558199 @default.
• W3036775154 cites W2058861807 @default.
• W3036775154 cites W2060602933 @default.
• W3036775154 cites W2078470782 @default.
• W3036775154 cites W2082438248 @default.
• W3036775154 cites W2084488755 @default.
• W3036775154 cites W2091149521 @default.
• W3036775154 cites W2092786186 @default.
• W3036775154 cites W2092879602 @default.
• W3036775154 cites W2108938583 @default.
• W3036775154 cites W2123730777 @default.
• W3036775154 cites W2132219921 @default.
• W3036775154 cites W2141605428 @default.
• W3036775154 cites W2142300072 @default.
• W3036775154 cites W2147636813 @default.
• W3036775154 cites W2149802841 @default.
• W3036775154 cites W2155290272 @default.
• W3036775154 cites W2156326104 @default.
• W3036775154 cites W2159013601 @default.
• W3036775154 cites W2162948131 @default.
• W3036775154 cites W2169152986 @default.
• W3036775154 cites W2257505379 @default.
• W3036775154 cites W2262548736 @default.
• W3036775154 cites W2272200006 @default.
• W3036775154 cites W2488287378 @default.
• W3036775154 cites W2578039103 @default.
• W3036775154 cites W2599851926 @default.
• W3036775154 cites W2600196148 @default.
• W3036775154 cites W2735082025 @default.
• W3036775154 cites W2767013949 @default.
• W3036775154 cites W2910128841 @default.
• W3036775154 cites W2917476942 @default.
• W3036775154 cites W2952117376 @default.
• W3036775154 doi "https://doi.org/10.3233/jad-200290" @default.
• W3036775154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32597808" @default.
• W3036775154 hasPublicationYear "2020" @default.
• W3036775154 type Work @default.
• W3036775154 sameAs 3036775154 @default.
• W3036775154 citedByCount "3" @default.
• W3036775154 countsByYear W30367751542022 @default.
• W3036775154 countsByYear W30367751542023 @default.
• W3036775154 crossrefType "journal-article" @default.
• W3036775154 hasAuthorship W3036775154A5007637621 @default.
• W3036775154 hasAuthorship W3036775154A5062475586 @default.
• W3036775154 hasAuthorship W3036775154A5072246865 @default.
• W3036775154 hasConcept C12554922 @default.
• W3036775154 hasConcept C169760540 @default.
• W3036775154 hasConcept C178790620 @default.
• W3036775154 hasConcept C185592680 @default.
• W3036775154 hasConcept C201571599 @default.
• W3036775154 hasConcept C4141045 @default.
• W3036775154 hasConcept C519063684 @default.
• W3036775154 hasConcept C86803240 @default.
• W3036775154 hasConcept C95444343 @default.
• W3036775154 hasConceptScore W3036775154C12554922 @default.
• W3036775154 hasConceptScore W3036775154C169760540 @default.
• W3036775154 hasConceptScore W3036775154C178790620 @default.
• W3036775154 hasConceptScore W3036775154C185592680 @default.
• W3036775154 hasConceptScore W3036775154C201571599 @default.
• W3036775154 hasConceptScore W3036775154C4141045 @default.
• W3036775154 hasConceptScore W3036775154C519063684 @default.
• W3036775154 hasConceptScore W3036775154C86803240 @default.
• W3036775154 hasConceptScore W3036775154C95444343 @default.
• W3036775154 hasIssue "3" @default.
• W3036775154 hasLocation W30367751541 @default.
• W3036775154 hasOpenAccess W3036775154 @default.
• W3036775154 hasPrimaryLocation W30367751541 @default.
• W3036775154 hasRelatedWork W1973993210 @default.
• W3036775154 hasRelatedWork W1996088859 @default.
• W3036775154 hasRelatedWork W2008313132 @default.
• W3036775154 hasRelatedWork W2068295046 @default.

• next